Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia
Recently, an increasing number of studies have highlighted the role of the cerebellum in language processing. However, the role of neural reorganization within the cerebellum as well as within the cerebrocerebellar system caused by poststroke aphasia remains unknown. To solve this problem, in the pr...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/3481423 |
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| author | Xiaotong Zhang Zhaocong Chen Na Li Jingfeng Liang Yan Zou Huixiang Wu Zhuang Kang Zulin Dou Weihong Qiu |
| author_facet | Xiaotong Zhang Zhaocong Chen Na Li Jingfeng Liang Yan Zou Huixiang Wu Zhuang Kang Zulin Dou Weihong Qiu |
| author_sort | Xiaotong Zhang |
| collection | DOAJ |
| description | Recently, an increasing number of studies have highlighted the role of the cerebellum in language processing. However, the role of neural reorganization within the cerebellum as well as within the cerebrocerebellar system caused by poststroke aphasia remains unknown. To solve this problem, in the present study, we investigated regional alterations of the cerebellum as well as the functional reorganization of the cerebrocerebellar circuit by combining structural and resting-state functional magnetic resonance imaging (fMRI) techniques. Twenty patients diagnosed with aphasia following left-hemispheric stroke and 20 age-matched healthy controls (HCs) were recruited in this study. The Western Aphasia Battery (WAB) test was used to assess the participants’ language ability. Gray matter volume, spontaneous brain activity, functional connectivity, and effective connectivity were examined in each participant. We discovered that gray matter volumes in right cerebellar lobule VI and right Crus I were significantly lower in the patient group, and the brain activity within these regions was significantly correlated with WAB scores. We also discovered decreased functional connectivity within the crossed cerebrocerebellar circuit, which was significantly correlated with WAB scores. Moreover, altered information flow between the cerebellum and the contralateral cerebrum was found. Together, our findings provide evidence for regional alterations within the cerebellum and the reorganization of the cerebrocerebellar system following poststroke aphasia and highlight the important role of the cerebellum in language processing within aphasic individuals after stroke. |
| format | Article |
| id | doaj-art-1d4dff162b9f4a9c8e088bc2f52b3b0a |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-1d4dff162b9f4a9c8e088bc2f52b3b0a2025-02-03T01:09:59ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/3481423Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke AphasiaXiaotong Zhang0Zhaocong Chen1Na Li2Jingfeng Liang3Yan Zou4Huixiang Wu5Zhuang Kang6Zulin Dou7Weihong Qiu8Department of Rehabilitation MedicineDepartment of Rehabilitation MedicineDepartment of Rehabilitation MedicineDepartment of Rehabilitation MedicineDepartment of RadiologyDepartment of Rehabilitation MedicineDepartment of RadiologyDepartment of Rehabilitation MedicineDepartment of Rehabilitation MedicineRecently, an increasing number of studies have highlighted the role of the cerebellum in language processing. However, the role of neural reorganization within the cerebellum as well as within the cerebrocerebellar system caused by poststroke aphasia remains unknown. To solve this problem, in the present study, we investigated regional alterations of the cerebellum as well as the functional reorganization of the cerebrocerebellar circuit by combining structural and resting-state functional magnetic resonance imaging (fMRI) techniques. Twenty patients diagnosed with aphasia following left-hemispheric stroke and 20 age-matched healthy controls (HCs) were recruited in this study. The Western Aphasia Battery (WAB) test was used to assess the participants’ language ability. Gray matter volume, spontaneous brain activity, functional connectivity, and effective connectivity were examined in each participant. We discovered that gray matter volumes in right cerebellar lobule VI and right Crus I were significantly lower in the patient group, and the brain activity within these regions was significantly correlated with WAB scores. We also discovered decreased functional connectivity within the crossed cerebrocerebellar circuit, which was significantly correlated with WAB scores. Moreover, altered information flow between the cerebellum and the contralateral cerebrum was found. Together, our findings provide evidence for regional alterations within the cerebellum and the reorganization of the cerebrocerebellar system following poststroke aphasia and highlight the important role of the cerebellum in language processing within aphasic individuals after stroke.http://dx.doi.org/10.1155/2022/3481423 |
| spellingShingle | Xiaotong Zhang Zhaocong Chen Na Li Jingfeng Liang Yan Zou Huixiang Wu Zhuang Kang Zulin Dou Weihong Qiu Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia Neural Plasticity |
| title | Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia |
| title_full | Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia |
| title_fullStr | Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia |
| title_full_unstemmed | Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia |
| title_short | Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia |
| title_sort | regional alteration within the cerebellum and the reorganization of the cerebrocerebellar system following poststroke aphasia |
| url | http://dx.doi.org/10.1155/2022/3481423 |
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