A multi-stage weakly supervised design for spheroid segmentation to explore mesenchymal stem cell differentiation dynamics

A multi-stage weakly supervised design for spheroid segmentation to explore mesenchymal stem cell differentiation dynamics

Abstract There is a growing interest in utilizing 3D culture models for stem cell and cancer cell research due to their closer resemblance to in vivo environments. In this study, human mesenchymal stem cells (MSCs) were cultured using adipocytes and osteocytes as differentiative mediums on varying c...

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Bibliographic Details
Main Authors: Arash Shahbazpoor Shahbazi, Farzin Irandoost, Reza Mahdavian, Seyedehsamaneh Shojaeilangari, Abdollah Allahvardi, Hossein Naderi-Manesh
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Bioinformatics
Subjects:
Convolutional neural network (CNN)
Deep learning
MSC differentiation dynamics
Segmentation
Spheroid
Stem cells
Online Access:https://doi.org/10.1186/s12859-024-06031-x
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