Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodological limitations

Expression characteristics of miR-502-5p/p53/NF-κB signaling pathway in patients with different degrees of knee osteoarthritis: a cross-sectional observational study with methodological limitations

Abstract Background and objective Knee osteoarthritis (KOA) is a prevalent degenerative joint disease affecting millions worldwide. Recent evidence has demonstrated the crucial role of non-coding RNAs, including microRNAs, in the pathogenesis of musculoskeletal disorders. While previous studies have...

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Bibliographic Details
Main Authors: Xiaozhe Zhang, Kesong Shi, Anmin Ruan, Pu Chen, Tao Zhang, Qingpu Wang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Knee osteoarthritis
miR-502-5p
p53
NF-κB
Synovitis
Observational study
Online Access:https://doi.org/10.1186/s13018-025-06134-y
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