Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies
Introduction. Liver disease patients have complex hemostatic defects leading to a delicate, unstable balance between bleeding and thrombosis. Conventional tests such as PT and APTT are unable to depict these defects completely. Aims. This study aimed at analyzing the abnormal effects of liver diseas...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/237351 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555168897433600 |
|---|---|
| author | Priyanka Saxena Chhagan Bihari Archana Rastogi Savita Agarwal Lovkesh Anand Shiv Kumar Sarin |
| author_facet | Priyanka Saxena Chhagan Bihari Archana Rastogi Savita Agarwal Lovkesh Anand Shiv Kumar Sarin |
| author_sort | Priyanka Saxena |
| collection | DOAJ |
| description | Introduction. Liver disease patients have complex hemostatic defects leading to a delicate, unstable balance between bleeding and thrombosis. Conventional tests such as PT and APTT are unable to depict these defects completely. Aims. This study aimed at analyzing the abnormal effects of liver disease on sonoclot signature by using sonoclot analyzer (which depicts the entire hemostatic pathway) and assessing the correlations between sonoclot variables and conventional coagulation tests. Material and Methods. Clinical and laboratory data from fifty inpatients of four subgroups of liver disease, including decompensated cirrhosis, chronic hepatitis, cirrhosis with HCC and acute-on-chronic liver failure were analyzed. All patients and controls were subjected to sonoclot analysis and correlated with routine coagulation parameters including platelet count, PT, APTT, fibrinogen, and D-dimer. Results. The sonoclot signatures demonstrated statistically significant abnormalities in patients with liver disease as compared to healthy controls. PT and APTT correlated positively with SONACT (P<0.008 and <0.0015, resp.) while platelet count and fibrinogen levels depicted significant positive and negative correlations with clot rate and SONACT respectively. Conclusion. Sonoclot analysis may prove to be an efficient tool to assess coagulopathies in liver disease patients. Clot rate could emerge as a potential predictor of hypercoagulability in these patients. |
| format | Article |
| id | doaj-art-1d2eb7954484410fbf374beba699bea1 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-1d2eb7954484410fbf374beba699bea12025-02-03T05:49:21ZengWileyAdvances in Hematology1687-91041687-91122013-01-01201310.1155/2013/237351237351Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation StudiesPriyanka Saxena0Chhagan Bihari1Archana Rastogi2Savita Agarwal3Lovkesh Anand4Shiv Kumar Sarin5Department of Hematology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110070, IndiaDepartment of Hematology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110070, IndiaDepartment of Pathology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110070, IndiaDepartment of Pathology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110070, IndiaDepartment of Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110070, IndiaDepartment of Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110070, IndiaIntroduction. Liver disease patients have complex hemostatic defects leading to a delicate, unstable balance between bleeding and thrombosis. Conventional tests such as PT and APTT are unable to depict these defects completely. Aims. This study aimed at analyzing the abnormal effects of liver disease on sonoclot signature by using sonoclot analyzer (which depicts the entire hemostatic pathway) and assessing the correlations between sonoclot variables and conventional coagulation tests. Material and Methods. Clinical and laboratory data from fifty inpatients of four subgroups of liver disease, including decompensated cirrhosis, chronic hepatitis, cirrhosis with HCC and acute-on-chronic liver failure were analyzed. All patients and controls were subjected to sonoclot analysis and correlated with routine coagulation parameters including platelet count, PT, APTT, fibrinogen, and D-dimer. Results. The sonoclot signatures demonstrated statistically significant abnormalities in patients with liver disease as compared to healthy controls. PT and APTT correlated positively with SONACT (P<0.008 and <0.0015, resp.) while platelet count and fibrinogen levels depicted significant positive and negative correlations with clot rate and SONACT respectively. Conclusion. Sonoclot analysis may prove to be an efficient tool to assess coagulopathies in liver disease patients. Clot rate could emerge as a potential predictor of hypercoagulability in these patients.http://dx.doi.org/10.1155/2013/237351 |
| spellingShingle | Priyanka Saxena Chhagan Bihari Archana Rastogi Savita Agarwal Lovkesh Anand Shiv Kumar Sarin Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies Advances in Hematology |
| title | Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies |
| title_full | Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies |
| title_fullStr | Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies |
| title_full_unstemmed | Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies |
| title_short | Sonoclot Signature Analysis in Patients with Liver Disease and Its Correlation with Conventional Coagulation Studies |
| title_sort | sonoclot signature analysis in patients with liver disease and its correlation with conventional coagulation studies |
| url | http://dx.doi.org/10.1155/2013/237351 |
| work_keys_str_mv | AT priyankasaxena sonoclotsignatureanalysisinpatientswithliverdiseaseanditscorrelationwithconventionalcoagulationstudies AT chhaganbihari sonoclotsignatureanalysisinpatientswithliverdiseaseanditscorrelationwithconventionalcoagulationstudies AT archanarastogi sonoclotsignatureanalysisinpatientswithliverdiseaseanditscorrelationwithconventionalcoagulationstudies AT savitaagarwal sonoclotsignatureanalysisinpatientswithliverdiseaseanditscorrelationwithconventionalcoagulationstudies AT lovkeshanand sonoclotsignatureanalysisinpatientswithliverdiseaseanditscorrelationwithconventionalcoagulationstudies AT shivkumarsarin sonoclotsignatureanalysisinpatientswithliverdiseaseanditscorrelationwithconventionalcoagulationstudies |