Application of Metabolomics to Study Effects of Bariatric Surgery
Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and simila...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6270875 |
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| author | Paulina Samczuk Michal Ciborowski Adam Kretowski |
| author_facet | Paulina Samczuk Michal Ciborowski Adam Kretowski |
| author_sort | Paulina Samczuk |
| collection | DOAJ |
| description | Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great potential for the comprehensive study of the dynamic alterations of the metabolome. It has been widely used in medicine, biology studies, biomarker discovery, and prognostic evaluations. Currently, several dozen metabolomics studies were performed to study the effects of bariatric surgery. LC-MS and NMR are the most frequently used techniques to study main effects of RYGB or SG. Research has yield many interesting results involving not only clinical parameters but also molecular modulations. Detected changes pertain to amino acid, lipids, carbohydrates, or gut microbiota alterations. It proves that including bariatric surgery to metabolic surgery is warranted. However, many molecular modulations after those procedures remain unexplained. Therefore, application of metabolomics to study this field seems to be a proper solution. New findings can suggest new directions of surgery technics modifications, contribute to broadening knowledge about obesity and diseases related to it, and perhaps develop nonsurgical methods of treatment in the future. |
| format | Article |
| id | doaj-art-1d269e76c4c94e1da4c88f0949f1de51 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1d269e76c4c94e1da4c88f0949f1de512025-02-03T06:08:37ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/62708756270875Application of Metabolomics to Study Effects of Bariatric SurgeryPaulina Samczuk0Michal Ciborowski1Adam Kretowski2Clinical Research Centre, Medical University of Białystok, Białystok, PolandClinical Research Centre, Medical University of Białystok, Białystok, PolandClinical Research Centre, Medical University of Białystok, Białystok, PolandBariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same token, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a relatively young science discipline, and similarly, it shows great potential for the comprehensive study of the dynamic alterations of the metabolome. It has been widely used in medicine, biology studies, biomarker discovery, and prognostic evaluations. Currently, several dozen metabolomics studies were performed to study the effects of bariatric surgery. LC-MS and NMR are the most frequently used techniques to study main effects of RYGB or SG. Research has yield many interesting results involving not only clinical parameters but also molecular modulations. Detected changes pertain to amino acid, lipids, carbohydrates, or gut microbiota alterations. It proves that including bariatric surgery to metabolic surgery is warranted. However, many molecular modulations after those procedures remain unexplained. Therefore, application of metabolomics to study this field seems to be a proper solution. New findings can suggest new directions of surgery technics modifications, contribute to broadening knowledge about obesity and diseases related to it, and perhaps develop nonsurgical methods of treatment in the future.http://dx.doi.org/10.1155/2018/6270875 |
| spellingShingle | Paulina Samczuk Michal Ciborowski Adam Kretowski Application of Metabolomics to Study Effects of Bariatric Surgery Journal of Diabetes Research |
| title | Application of Metabolomics to Study Effects of Bariatric Surgery |
| title_full | Application of Metabolomics to Study Effects of Bariatric Surgery |
| title_fullStr | Application of Metabolomics to Study Effects of Bariatric Surgery |
| title_full_unstemmed | Application of Metabolomics to Study Effects of Bariatric Surgery |
| title_short | Application of Metabolomics to Study Effects of Bariatric Surgery |
| title_sort | application of metabolomics to study effects of bariatric surgery |
| url | http://dx.doi.org/10.1155/2018/6270875 |
| work_keys_str_mv | AT paulinasamczuk applicationofmetabolomicstostudyeffectsofbariatricsurgery AT michalciborowski applicationofmetabolomicstostudyeffectsofbariatricsurgery AT adamkretowski applicationofmetabolomicstostudyeffectsofbariatricsurgery |