Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes
We analyzed (a) insulin sensitivity (IS) and (b) glutathione peroxidase (GSH-Px), glutathione reductase (GR), and superoxide dismutase (SOD) antioxidant enzyme activity in type 2 diabetic (T2D) patients with atherothrombotic infarction (ATI) (group A), lacunar infarction (LI) (B), or without stroke...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/401609 |
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| author | Aleksandra Jotic Nadezda Covickovic Sternic Vladimir S. Kostic Katarina Lalic Tanja Milicic Milija Mijajlovic Ljiljana Lukic Milorad Civcic Emina Colak Marija Macesic Jelena P. Seferovic Sandra Aleksic Nebojsa M. Lalic |
| author_facet | Aleksandra Jotic Nadezda Covickovic Sternic Vladimir S. Kostic Katarina Lalic Tanja Milicic Milija Mijajlovic Ljiljana Lukic Milorad Civcic Emina Colak Marija Macesic Jelena P. Seferovic Sandra Aleksic Nebojsa M. Lalic |
| author_sort | Aleksandra Jotic |
| collection | DOAJ |
| description | We analyzed (a) insulin sensitivity (IS) and (b) glutathione peroxidase (GSH-Px), glutathione reductase (GR), and superoxide dismutase (SOD) antioxidant enzyme activity in type 2 diabetic (T2D) patients with atherothrombotic infarction (ATI) (group A), lacunar infarction (LI) (B), or without stroke (C) and in nondiabetics with ATI (D), LI (E), or without stroke (F). ATI and LI were confirmed by brain imaging IS levels were determined by
minimal model (Si index), and the enzyme activity by spectrophotometry. In T2D patients, Si was lower in A and B versus
C (1.14±0.58, 1.00±0.26 versus 3.14±0.62 min−1/mU/l × 104, P<0.001) and in nondiabetics in D and E versus F (3.38±0.77, 3.03±0.72 versus 6.03±1.69 min−1/mU/l × 104, P<0.001). Also, GSH-Px and GR activities were lower in A and B versus C (GSH-Px: 21.96±3.56, 22.51±1.23 versus 25.12±1.67; GR: 44.37±3.58, 43.50±2.39 versus 48.58±3.67 U/gHb; P<0.001) and in D and E versus F (GSH-Px: 24.75±3.02, 25.57±1.92 versus 28.56±3.91; GR: 48.27±6.81, 49.17±6.24 versus 53.67±3.96 U/gHb; P<0.001). Decreases in Si and GR were significantly related to both ATI and LI in T2D. Our results showed that decreased IS and impaired antioxidant enzymes activity influence ischemic stroke subtypes in T2D. The influence of insulin resistance might be exerted on the level of glutathione-dependent antioxidant enzymes. |
| format | Article |
| id | doaj-art-1d20a16fc6c7490d94c9f00b3f17c789 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-1d20a16fc6c7490d94c9f00b3f17c7892025-08-20T03:54:51ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/401609401609Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke SubtypesAleksandra Jotic0Nadezda Covickovic Sternic1Vladimir S. Kostic2Katarina Lalic3Tanja Milicic4Milija Mijajlovic5Ljiljana Lukic6Milorad Civcic7Emina Colak8Marija Macesic9Jelena P. Seferovic10Sandra Aleksic11Nebojsa M. Lalic12Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000 Belgrade, SerbiaClinic for Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Neurology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaInstitute of Medical Biochemistry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaClinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 13, 11000 Belgrade, SerbiaWe analyzed (a) insulin sensitivity (IS) and (b) glutathione peroxidase (GSH-Px), glutathione reductase (GR), and superoxide dismutase (SOD) antioxidant enzyme activity in type 2 diabetic (T2D) patients with atherothrombotic infarction (ATI) (group A), lacunar infarction (LI) (B), or without stroke (C) and in nondiabetics with ATI (D), LI (E), or without stroke (F). ATI and LI were confirmed by brain imaging IS levels were determined by minimal model (Si index), and the enzyme activity by spectrophotometry. In T2D patients, Si was lower in A and B versus C (1.14±0.58, 1.00±0.26 versus 3.14±0.62 min−1/mU/l × 104, P<0.001) and in nondiabetics in D and E versus F (3.38±0.77, 3.03±0.72 versus 6.03±1.69 min−1/mU/l × 104, P<0.001). Also, GSH-Px and GR activities were lower in A and B versus C (GSH-Px: 21.96±3.56, 22.51±1.23 versus 25.12±1.67; GR: 44.37±3.58, 43.50±2.39 versus 48.58±3.67 U/gHb; P<0.001) and in D and E versus F (GSH-Px: 24.75±3.02, 25.57±1.92 versus 28.56±3.91; GR: 48.27±6.81, 49.17±6.24 versus 53.67±3.96 U/gHb; P<0.001). Decreases in Si and GR were significantly related to both ATI and LI in T2D. Our results showed that decreased IS and impaired antioxidant enzymes activity influence ischemic stroke subtypes in T2D. The influence of insulin resistance might be exerted on the level of glutathione-dependent antioxidant enzymes.http://dx.doi.org/10.1155/2013/401609 |
| spellingShingle | Aleksandra Jotic Nadezda Covickovic Sternic Vladimir S. Kostic Katarina Lalic Tanja Milicic Milija Mijajlovic Ljiljana Lukic Milorad Civcic Emina Colak Marija Macesic Jelena P. Seferovic Sandra Aleksic Nebojsa M. Lalic Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes International Journal of Endocrinology |
| title | Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes |
| title_full | Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes |
| title_fullStr | Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes |
| title_full_unstemmed | Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes |
| title_short | Type 2 Diabetic Patients with Ischemic Stroke: Decreased Insulin Sensitivity and Decreases in Antioxidant Enzyme Activity Are Related to Different Stroke Subtypes |
| title_sort | type 2 diabetic patients with ischemic stroke decreased insulin sensitivity and decreases in antioxidant enzyme activity are related to different stroke subtypes |
| url | http://dx.doi.org/10.1155/2013/401609 |
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