Bordetella adenylate cyclase toxin elicits chromatin remodeling and transcriptional reprogramming that blocks differentiation of monocytes into macrophages

Bordetella adenylate cyclase toxin elicits chromatin remodeling and transcriptional reprogramming that blocks differentiation of monocytes into macrophages

ABSTRACT Bordetella pertussis infects human upper airways and deploys an array of immunosuppressive virulence factors, among which the adenylate cyclase toxin (CyaA) plays a prominent role in disarming host phagocytes. CyaA binds the complement receptor-3 (CR3 aka αMβ2 integrin CD11b/CD18 or Mac-1)...

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Main Authors: Jawid Nazir Ahmad, Martin Modrak, Marketa Fajfrova, Blanca Martin-Borja Sotoca, Oldrich Benada, Peter Sebo
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
macrophages
differentiation
monocytes
RTX toxins
cyclic AMP
Bordetella pertussis
Online Access:https://journals.asm.org/doi/10.1128/mbio.00138-25
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https://journals.asm.org/doi/10.1128/mbio.00138-25

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