The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review
Metabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/1/9 |
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| author | Chunhao Gao Nengyun Gong Fangtian Chen Shiran Hu Qingxin Zhou Xiang Gao |
| author_facet | Chunhao Gao Nengyun Gong Fangtian Chen Shiran Hu Qingxin Zhou Xiang Gao |
| author_sort | Chunhao Gao |
| collection | DOAJ |
| description | Metabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent and ameliorate MS. Astaxanthin (AST), a carotenoid found in various marine organisms, exhibits exceptional antioxidant properties and holds great promise as a natural compound that improves MS. This article introduces the basic properties of AST, including its absorptance and metabolic pathways, along with various isomers. Most importantly, we comprehensively review the effects and mechanisms of AST on improving the primary components of MS. These mechanisms primarily involve regulating signal transduction, transport, or metabolic pathways within the body, as well as influencing intestinal microbiota and metabolites, thereby exerting positive effects on metabolism and inhibiting the occurrence of MS. This review emphasizes the potential efficacy of AST in managing MS. However, more studies are needed to confirm the clinical effect of AST on MS and reveal potential molecular mechanisms. |
| format | Article |
| id | doaj-art-1d0b494b69cd48adaf50b01288bd95f0 |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-1d0b494b69cd48adaf50b01288bd95f02025-01-24T13:39:26ZengMDPI AGMarine Drugs1660-33972024-12-01231910.3390/md23010009The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive ReviewChunhao Gao0Nengyun Gong1Fangtian Chen2Shiran Hu3Qingxin Zhou4Xiang Gao5College of Life Sciences, Qingdao University, Qingdao 266071, ChinaCollege of Life Sciences, Qingdao University, Qingdao 266071, ChinaDepartment of Marine Technology, Rizhao Polytechnic, Shandong Engineering and Technology Research Center for Marine Crustacean Resources Comprehensive Utilization, Shandong Engineering Research Center for Efficient Utilization Technology of Marine Food Resources, Rizhao Key Laboratory of Efficient Utilization of Marine Food Resources, Rizhao 276826, ChinaCollege of Life Sciences, Qingdao University, Qingdao 266071, ChinaDepartment of Marine Technology, Rizhao Polytechnic, Shandong Engineering and Technology Research Center for Marine Crustacean Resources Comprehensive Utilization, Shandong Engineering Research Center for Efficient Utilization Technology of Marine Food Resources, Rizhao Key Laboratory of Efficient Utilization of Marine Food Resources, Rizhao 276826, ChinaCollege of Life Sciences, Qingdao University, Qingdao 266071, ChinaMetabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent and ameliorate MS. Astaxanthin (AST), a carotenoid found in various marine organisms, exhibits exceptional antioxidant properties and holds great promise as a natural compound that improves MS. This article introduces the basic properties of AST, including its absorptance and metabolic pathways, along with various isomers. Most importantly, we comprehensively review the effects and mechanisms of AST on improving the primary components of MS. These mechanisms primarily involve regulating signal transduction, transport, or metabolic pathways within the body, as well as influencing intestinal microbiota and metabolites, thereby exerting positive effects on metabolism and inhibiting the occurrence of MS. This review emphasizes the potential efficacy of AST in managing MS. However, more studies are needed to confirm the clinical effect of AST on MS and reveal potential molecular mechanisms.https://www.mdpi.com/1660-3397/23/1/9astaxanthinmetabolic syndromeobesityinsulin resistancedyslipidemia |
| spellingShingle | Chunhao Gao Nengyun Gong Fangtian Chen Shiran Hu Qingxin Zhou Xiang Gao The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review Marine Drugs astaxanthin metabolic syndrome obesity insulin resistance dyslipidemia |
| title | The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review |
| title_full | The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review |
| title_fullStr | The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review |
| title_full_unstemmed | The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review |
| title_short | The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review |
| title_sort | effects of astaxanthin on metabolic syndrome a comprehensive review |
| topic | astaxanthin metabolic syndrome obesity insulin resistance dyslipidemia |
| url | https://www.mdpi.com/1660-3397/23/1/9 |
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