Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity
IntroductionStimulator of interferon response cGAMP interactor (STING) is essential for both innate and adaptive immunity. However, a comprehensive molecular characterization of STING expression across hematological malignancies is lacking.MethodsIn this study, the pan-blood-cancer landscape related...
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Frontiers Media S.A.
2025-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1477100/full |
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| author | Xiang-mei Wen Xiang-mei Wen Xiang-mei Wen Zi-jun Xu Zi-jun Xu Zi-jun Xu Ji-chun Ma Ji-chun Ma Ji-chun Ma Min-jie Zhang Min-jie Zhang Min-jie Zhang Ye Jin Ye Jin Jiang Lin Jiang Lin Jiang Lin Jun Qian Jun Qian Yuan-yuan Fang Yuan-yuan Fang Yuan-yuan Fang Shu-yu Luo Shu-yu Luo Shu-yu Luo Zhen-wei Mao |
| author_facet | Xiang-mei Wen Xiang-mei Wen Xiang-mei Wen Zi-jun Xu Zi-jun Xu Zi-jun Xu Ji-chun Ma Ji-chun Ma Ji-chun Ma Min-jie Zhang Min-jie Zhang Min-jie Zhang Ye Jin Ye Jin Jiang Lin Jiang Lin Jiang Lin Jun Qian Jun Qian Yuan-yuan Fang Yuan-yuan Fang Yuan-yuan Fang Shu-yu Luo Shu-yu Luo Shu-yu Luo Zhen-wei Mao |
| author_sort | Xiang-mei Wen |
| collection | DOAJ |
| description | IntroductionStimulator of interferon response cGAMP interactor (STING) is essential for both innate and adaptive immunity. However, a comprehensive molecular characterization of STING expression across hematological malignancies is lacking.MethodsIn this study, the pan-blood-cancer landscape related to STING expression was identified using the GTEx, CCLE, Hemap, and TCGA databases, and the potential value for predicting prognosis was investigated. The relationship between STING expression and immune cell enrichment was assessed in the Hemap database. Moreover, the value of STING in predicting the efficacy of immunotherapy was validated using tumor immune dysfunction and exclusion (TIDE) biomarkers and real-world immunotherapy datasets.Results and DiscussionSTING was found to be relatively highly expressed in acute myeloid leukemia (AML) and chronic myeloid leukemia, with higher STING expression correlated with poorer prognosis in AML. STING expression was positively correlated with immune-related pathways such as IFN-gamma response, IFN-alpha response, and inflammatory response. Cytolytic score and STING expression were positively correlated in some hematological tumors, especially chronic lymphocytic leukemia and mantle cell lymphoma. Interestingly, STING expression was negatively correlated with TIDE biomarkers in AML, suggesting that AML patients with a high STING expression level may benefit from immunologic treatment. Our findings contribute a molecular characterization of STING across hematological malignancies, facilitating the development of individualized prognosis and treatment strategies. |
| format | Article |
| id | doaj-art-1d06731678b64abca88ad0a24c6f12b3 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-1d06731678b64abca88ad0a24c6f12b32025-02-05T07:32:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.14771001477100Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunityXiang-mei Wen0Xiang-mei Wen1Xiang-mei Wen2Zi-jun Xu3Zi-jun Xu4Zi-jun Xu5Ji-chun Ma6Ji-chun Ma7Ji-chun Ma8Min-jie Zhang9Min-jie Zhang10Min-jie Zhang11Ye Jin12Ye Jin13Jiang Lin14Jiang Lin15Jiang Lin16Jun Qian17Jun Qian18Yuan-yuan Fang19Yuan-yuan Fang20Yuan-yuan Fang21Shu-yu Luo22Shu-yu Luo23Shu-yu Luo24Zhen-wei Mao25Laboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhejiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaLaboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhejiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaLaboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhejiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaLaboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhejiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaLaboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhejiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaLaboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhejiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaLaboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhejiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaZhenjiang Clinical Research Center of Hematology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaIntroductionStimulator of interferon response cGAMP interactor (STING) is essential for both innate and adaptive immunity. However, a comprehensive molecular characterization of STING expression across hematological malignancies is lacking.MethodsIn this study, the pan-blood-cancer landscape related to STING expression was identified using the GTEx, CCLE, Hemap, and TCGA databases, and the potential value for predicting prognosis was investigated. The relationship between STING expression and immune cell enrichment was assessed in the Hemap database. Moreover, the value of STING in predicting the efficacy of immunotherapy was validated using tumor immune dysfunction and exclusion (TIDE) biomarkers and real-world immunotherapy datasets.Results and DiscussionSTING was found to be relatively highly expressed in acute myeloid leukemia (AML) and chronic myeloid leukemia, with higher STING expression correlated with poorer prognosis in AML. STING expression was positively correlated with immune-related pathways such as IFN-gamma response, IFN-alpha response, and inflammatory response. Cytolytic score and STING expression were positively correlated in some hematological tumors, especially chronic lymphocytic leukemia and mantle cell lymphoma. Interestingly, STING expression was negatively correlated with TIDE biomarkers in AML, suggesting that AML patients with a high STING expression level may benefit from immunologic treatment. Our findings contribute a molecular characterization of STING across hematological malignancies, facilitating the development of individualized prognosis and treatment strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1477100/fullSTINGhematological malignanciesprognosistumor immune microenvironmentimmunotherapy |
| spellingShingle | Xiang-mei Wen Xiang-mei Wen Xiang-mei Wen Zi-jun Xu Zi-jun Xu Zi-jun Xu Ji-chun Ma Ji-chun Ma Ji-chun Ma Min-jie Zhang Min-jie Zhang Min-jie Zhang Ye Jin Ye Jin Jiang Lin Jiang Lin Jiang Lin Jun Qian Jun Qian Yuan-yuan Fang Yuan-yuan Fang Yuan-yuan Fang Shu-yu Luo Shu-yu Luo Shu-yu Luo Zhen-wei Mao Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity Frontiers in Immunology STING hematological malignancies prognosis tumor immune microenvironment immunotherapy |
| title | Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity |
| title_full | Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity |
| title_fullStr | Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity |
| title_full_unstemmed | Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity |
| title_short | Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity |
| title_sort | bioinformatic characterization of sting expression in hematological malignancies reveals association with prognosis and anti tumor immunity |
| topic | STING hematological malignancies prognosis tumor immune microenvironment immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1477100/full |
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