Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression
MODERATE-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1α) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phago...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09511920410001713484 |
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| author | Rosaria Alba Merendino Giuseppe Di Pasquale Filippo De Luca Laura Di Pasquale Edoardo Ferlazzo Gabriella Martino Maura Carmela Palumbo Fortunato Morabito Sebastiano Gangemi |
| author_facet | Rosaria Alba Merendino Giuseppe Di Pasquale Filippo De Luca Laura Di Pasquale Edoardo Ferlazzo Gabriella Martino Maura Carmela Palumbo Fortunato Morabito Sebastiano Gangemi |
| author_sort | Rosaria Alba Merendino |
| collection | DOAJ |
| description | MODERATE-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1α) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1α in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1α was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease. |
| format | Article |
| id | doaj-art-1ced6d5cec384724ad762dae7b83bf00 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1ced6d5cec384724ad762dae7b83bf002025-02-03T00:59:09ZengWileyMediators of Inflammation0962-93511466-18612004-01-0113320520710.1080/09511920410001713484Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depressionRosaria Alba Merendino0Giuseppe Di Pasquale1Filippo De Luca2Laura Di Pasquale3Edoardo Ferlazzo4Gabriella Martino5Maura Carmela Palumbo6Fortunato Morabito7Sebastiano Gangemi8Chair of Immunopathology, Department of Human Pathology, University of Messina, ItalyDepartment of Pediatrics Science, University of Messina, ItalyDepartment of Pediatrics Science, University of Messina, ItalyDepartment of Pediatrics Science, University of Messina, ItalySchool and Division of Neurology, Department of Neurosciences, University of Messina, ItalyDepartment of Neurosciences, Psychiatry and Anesthesiology, University of Messina, ItalySPDC, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, ItalyBone Marrow Transplant Unit, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, ItalySchool of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina, ItalyMODERATE-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1α) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1α in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1α was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.http://dx.doi.org/10.1080/09511920410001713484Moderate-severe depressionfractalkineMacrophage inflammatory protein-1 alphaSerum. |
| spellingShingle | Rosaria Alba Merendino Giuseppe Di Pasquale Filippo De Luca Laura Di Pasquale Edoardo Ferlazzo Gabriella Martino Maura Carmela Palumbo Fortunato Morabito Sebastiano Gangemi Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression Mediators of Inflammation Moderate-severe depression fractalkine Macrophage inflammatory protein-1 alpha Serum. |
| title | Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression |
| title_full | Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression |
| title_fullStr | Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression |
| title_full_unstemmed | Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression |
| title_short | Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression |
| title_sort | involvement of fractalkine and macrophage inflammatory protein 1 alpha in moderate severe depression |
| topic | Moderate-severe depression fractalkine Macrophage inflammatory protein-1 alpha Serum. |
| url | http://dx.doi.org/10.1080/09511920410001713484 |
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