Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection
BackgroundAs a rare condition, sporadic non-ampullary duodenal adenomas (SNADAs) are typically asymptomatic and diagnosed incidentally. It warrants treatment due to the high risk of malignant transformation. However, giant SNADAs, especially those treated using hybrid endoscopic submucosal dissectio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1511454/full |
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| author | Jun-Jie Hou Liang Ding Yan-Fei Yang Wei-Wei Li |
| author_facet | Jun-Jie Hou Liang Ding Yan-Fei Yang Wei-Wei Li |
| author_sort | Jun-Jie Hou |
| collection | DOAJ |
| description | BackgroundAs a rare condition, sporadic non-ampullary duodenal adenomas (SNADAs) are typically asymptomatic and diagnosed incidentally. It warrants treatment due to the high risk of malignant transformation. However, giant SNADAs, especially those treated using hybrid endoscopic submucosal dissection (ESD), are exceedingly rare, and to our knowledge, this condition has not been reported previously.Case presentationA 69-year-old Chinese male patient was diagnosed with an incidentally discovered giant SNADA. Given the size and location and the patient’s non-invasive request, we performed hybrid ESD to completely resect a giant SNADA (4.5*2.8*1.0cm) without postoperative discomfort or complications. Final pathology confirmed a margin-negative tubulovillous adenoma with low-grade intraepithelial neoplasia.ConclusionWe present a rare case of a giant SNADA that was successfully dissected using hybrid ESD. Further, we provide a brief review, discuss the treatment protocol of this case, and provide a new perspective for the future diagnosis and treatment of a giant SNADA. |
| format | Article |
| id | doaj-art-1ceaf6605c6743e28e2f83197d5a6573 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-1ceaf6605c6743e28e2f83197d5a65732025-08-20T03:47:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15114541511454Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissectionJun-Jie HouLiang DingYan-Fei YangWei-Wei LiBackgroundAs a rare condition, sporadic non-ampullary duodenal adenomas (SNADAs) are typically asymptomatic and diagnosed incidentally. It warrants treatment due to the high risk of malignant transformation. However, giant SNADAs, especially those treated using hybrid endoscopic submucosal dissection (ESD), are exceedingly rare, and to our knowledge, this condition has not been reported previously.Case presentationA 69-year-old Chinese male patient was diagnosed with an incidentally discovered giant SNADA. Given the size and location and the patient’s non-invasive request, we performed hybrid ESD to completely resect a giant SNADA (4.5*2.8*1.0cm) without postoperative discomfort or complications. Final pathology confirmed a margin-negative tubulovillous adenoma with low-grade intraepithelial neoplasia.ConclusionWe present a rare case of a giant SNADA that was successfully dissected using hybrid ESD. Further, we provide a brief review, discuss the treatment protocol of this case, and provide a new perspective for the future diagnosis and treatment of a giant SNADA.https://www.frontiersin.org/articles/10.3389/fonc.2025.1511454/fullhybrid endoscopic submucosal dissectionsporadic non-ampullary duodenal adenomasgiant duodenal adenomaendoscopic therapycase report |
| spellingShingle | Jun-Jie Hou Liang Ding Yan-Fei Yang Wei-Wei Li Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection Frontiers in Oncology hybrid endoscopic submucosal dissection sporadic non-ampullary duodenal adenomas giant duodenal adenoma endoscopic therapy case report |
| title | Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection |
| title_full | Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection |
| title_fullStr | Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection |
| title_full_unstemmed | Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection |
| title_short | Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection |
| title_sort | case report a rare case of a giant sporadic non ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection |
| topic | hybrid endoscopic submucosal dissection sporadic non-ampullary duodenal adenomas giant duodenal adenoma endoscopic therapy case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1511454/full |
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