Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels
IntroductionWomen with low-risk endometrial cancer, as defined by the Korean Gynecologic Oncology Group (KGOG) criteria, have a low risk of lymph node metastasis and an excellent prognosis without lymphadenectomy. However, it is unclear whether lymphadenectomy should be performed in premenopausal wo...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1510988/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592625351262208 |
|---|---|
| author | Jeong Min Song Ala Aiob Ala Aiob Kidong Kim Kidong Kim Kwang Beom Lee Sokbom Kang Chae Hyeong Lee Se Ik Kim Nam Kyeong Kim Dae Hoon Jeong |
| author_facet | Jeong Min Song Ala Aiob Ala Aiob Kidong Kim Kidong Kim Kwang Beom Lee Sokbom Kang Chae Hyeong Lee Se Ik Kim Nam Kyeong Kim Dae Hoon Jeong |
| author_sort | Jeong Min Song |
| collection | DOAJ |
| description | IntroductionWomen with low-risk endometrial cancer, as defined by the Korean Gynecologic Oncology Group (KGOG) criteria, have a low risk of lymph node metastasis and an excellent prognosis without lymphadenectomy. However, it is unclear whether lymphadenectomy should be performed in premenopausal women who meet the KGOG criteria other than elevated cancer antigen 125 (CA125) levels, because the CA125 level can be elevated by benign conditions. We investigated the patterns of metastasis and recurrence to assess the value of lymphadenectomy in this population.MethodsPremenopausal women with endometrial cancer meeting the KGOG criteria, except for those with elevated CA125 levels, were eligible. The characteristics of the eligible women were collected from seven institutes in the Republic of Korea by reviewing their medical records. Recurrence-free survival (RFS) was estimated using the Kaplan–Meier method and compared using the log-rank test.ResultsSeventy-three patients were included. Of 62 women who underwent lymphadenectomy, only two (3.2%) had lymph node metastasis. Eighteen women (24.7%) received adjuvant therapy. At a median follow-up of 59 months, the 5-year RFS was 88.8%. Five women (7%) experienced recurrence, two had lymph node recurrence, and three had non-nodal recurrence. RFS was similar between the women who did and did not undergo lymphadenectomy (P=0.737).ConclusionPremenopausal women who had elevated CA125 levels but met all other KGOG criteria showed a low risk of lymph node metastasis and recurrence as well as a good prognosis. Therefore, lymphadenectomy can be omitted in this population. |
| format | Article |
| id | doaj-art-1ce897101bec456cb8eea429785e2999 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-1ce897101bec456cb8eea429785e29992025-01-21T05:43:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15109881510988Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levelsJeong Min Song0Ala Aiob1Ala Aiob2Kidong Kim3Kidong Kim4Kwang Beom Lee5Sokbom Kang6Chae Hyeong Lee7Se Ik Kim8Nam Kyeong Kim9Dae Hoon Jeong10Department of Obstetrics and Gynecology, Kyung Hee University School of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, IsraelAzrieli Faculty of Medicine, Bar Ilan University, Safed, IsraelDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of KoreaCenter for Gynecologic Cancer, National Cancer Center, Goyang, Republic of KoreaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Dongguk University, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of KoreaDepartment of Obstetrics and Gynecology, Busan Paik Hospital, Paik Institute for Clinical Research, Inje University, Busan, Republic of KoreaIntroductionWomen with low-risk endometrial cancer, as defined by the Korean Gynecologic Oncology Group (KGOG) criteria, have a low risk of lymph node metastasis and an excellent prognosis without lymphadenectomy. However, it is unclear whether lymphadenectomy should be performed in premenopausal women who meet the KGOG criteria other than elevated cancer antigen 125 (CA125) levels, because the CA125 level can be elevated by benign conditions. We investigated the patterns of metastasis and recurrence to assess the value of lymphadenectomy in this population.MethodsPremenopausal women with endometrial cancer meeting the KGOG criteria, except for those with elevated CA125 levels, were eligible. The characteristics of the eligible women were collected from seven institutes in the Republic of Korea by reviewing their medical records. Recurrence-free survival (RFS) was estimated using the Kaplan–Meier method and compared using the log-rank test.ResultsSeventy-three patients were included. Of 62 women who underwent lymphadenectomy, only two (3.2%) had lymph node metastasis. Eighteen women (24.7%) received adjuvant therapy. At a median follow-up of 59 months, the 5-year RFS was 88.8%. Five women (7%) experienced recurrence, two had lymph node recurrence, and three had non-nodal recurrence. RFS was similar between the women who did and did not undergo lymphadenectomy (P=0.737).ConclusionPremenopausal women who had elevated CA125 levels but met all other KGOG criteria showed a low risk of lymph node metastasis and recurrence as well as a good prognosis. Therefore, lymphadenectomy can be omitted in this population.https://www.frontiersin.org/articles/10.3389/fonc.2024.1510988/fullendometrial cancerlymphadenectomyCA125premenopausallymphatic metastasis |
| spellingShingle | Jeong Min Song Ala Aiob Ala Aiob Kidong Kim Kidong Kim Kwang Beom Lee Sokbom Kang Chae Hyeong Lee Se Ik Kim Nam Kyeong Kim Dae Hoon Jeong Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels Frontiers in Oncology endometrial cancer lymphadenectomy CA125 premenopausal lymphatic metastasis |
| title | Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels |
| title_full | Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels |
| title_fullStr | Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels |
| title_full_unstemmed | Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels |
| title_short | Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels |
| title_sort | prognosis of premenopausal women with low risk endometrial cancer but elevated ca125 levels |
| topic | endometrial cancer lymphadenectomy CA125 premenopausal lymphatic metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1510988/full |
| work_keys_str_mv | AT jeongminsong prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT alaaiob prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT alaaiob prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT kidongkim prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT kidongkim prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT kwangbeomlee prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT sokbomkang prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT chaehyeonglee prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT seikkim prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT namkyeongkim prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels AT daehoonjeong prognosisofpremenopausalwomenwithlowriskendometrialcancerbutelevatedca125levels |