The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures
Aim. Differentiation of malignant and benign strictures constitutes a problem despite the increasing experience of the endoscopists, radiologists, and pathologists. The aim of our study is to determine the factors that affect the efficacy of the ERCP guided brush cytology in PBS and to evaluate its...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/580254 |
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| author | Ufuk Barış Kuzu Bülent Ödemiş Nesrin Turhan Erkan Parlak Selçuk Dişibeyaz Nuretdin Suna Erkin Öztaş Muhammet Yener Akpınar Adem Aksoy Serkan Torun Hakan Yıldız Ertuğrul Kayaçetin |
| author_facet | Ufuk Barış Kuzu Bülent Ödemiş Nesrin Turhan Erkan Parlak Selçuk Dişibeyaz Nuretdin Suna Erkin Öztaş Muhammet Yener Akpınar Adem Aksoy Serkan Torun Hakan Yıldız Ertuğrul Kayaçetin |
| author_sort | Ufuk Barış Kuzu |
| collection | DOAJ |
| description | Aim. Differentiation of malignant and benign strictures constitutes a problem despite the increasing experience of the endoscopists, radiologists, and pathologists. The aim of our study is to determine the factors that affect the efficacy of the ERCP guided brush cytology in PBS and to evaluate its diagnostic success when used alone and together with tumor markers. Method. The data from brush cytologies of 301 PBS patients were collected retrospectively and analyzed. The final diagnosis was approved based on the histological examination of the tissue taken surgically or by other methods. In the absence of a histological diagnosis, the final diagnosis was based on radiological studies or the results of a 12-month clinical follow up. Results. A total of 28 patients were excluded from the study. From the remaining 273 patients 299 samples were analyzed. The sensitivity and the specificity of brush cytology in diagnosing malignancy are 62.4% and 97.7, respectively. The sensitivity of brush cytology increased to 94.1% when combined with CA-19.9 and CA-125. Conclusion. Brush cytology is a useful method in diagnosing pancreaticobiliary strictures. Advanced age, stricture dilatation before sampling, the presence of a mass identified by radiological studies, high levels of CA-19.9, ALT, and total bilirubin increase the sensitivity of brush cytology. |
| format | Article |
| id | doaj-art-1ce4a860aaa649d88e2d478ad31f491c |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-1ce4a860aaa649d88e2d478ad31f491c2025-02-03T01:11:47ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/580254580254The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary StricturesUfuk Barış Kuzu0Bülent Ödemiş1Nesrin Turhan2Erkan Parlak3Selçuk Dişibeyaz4Nuretdin Suna5Erkin Öztaş6Muhammet Yener Akpınar7Adem Aksoy8Serkan Torun9Hakan Yıldız10Ertuğrul Kayaçetin11Department of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Pathology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyDepartment of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, TurkeyAim. Differentiation of malignant and benign strictures constitutes a problem despite the increasing experience of the endoscopists, radiologists, and pathologists. The aim of our study is to determine the factors that affect the efficacy of the ERCP guided brush cytology in PBS and to evaluate its diagnostic success when used alone and together with tumor markers. Method. The data from brush cytologies of 301 PBS patients were collected retrospectively and analyzed. The final diagnosis was approved based on the histological examination of the tissue taken surgically or by other methods. In the absence of a histological diagnosis, the final diagnosis was based on radiological studies or the results of a 12-month clinical follow up. Results. A total of 28 patients were excluded from the study. From the remaining 273 patients 299 samples were analyzed. The sensitivity and the specificity of brush cytology in diagnosing malignancy are 62.4% and 97.7, respectively. The sensitivity of brush cytology increased to 94.1% when combined with CA-19.9 and CA-125. Conclusion. Brush cytology is a useful method in diagnosing pancreaticobiliary strictures. Advanced age, stricture dilatation before sampling, the presence of a mass identified by radiological studies, high levels of CA-19.9, ALT, and total bilirubin increase the sensitivity of brush cytology.http://dx.doi.org/10.1155/2015/580254 |
| spellingShingle | Ufuk Barış Kuzu Bülent Ödemiş Nesrin Turhan Erkan Parlak Selçuk Dişibeyaz Nuretdin Suna Erkin Öztaş Muhammet Yener Akpınar Adem Aksoy Serkan Torun Hakan Yıldız Ertuğrul Kayaçetin The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures Gastroenterology Research and Practice |
| title | The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures |
| title_full | The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures |
| title_fullStr | The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures |
| title_full_unstemmed | The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures |
| title_short | The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures |
| title_sort | diagnostic value of brush cytology alone and in combination with tumor markers in pancreaticobiliary strictures |
| url | http://dx.doi.org/10.1155/2015/580254 |
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