Alpha Errors, Beta Errors and Negative Trials
Reports of negative trials arc increasing in number as standard therapy for many gastrointestinal diseases is refined. The validity of a negative report depends on the number of patients in the trial, the alpha and bern error and the difference in efficacy which the trial is able to detect. The rela...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1988-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1988/523841 |
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| Summary: | Reports of negative trials arc increasing in number as standard therapy
for many gastrointestinal diseases is refined. The validity of a negative report depends
on the number of patients in the trial, the alpha and bern error and the difference in
efficacy which the trial is able to detect. The relationship between these parameters
is discussed and a formula given for the calculation of trial size. All reports of negative
trials should include not only the number of patients involved and the level of
significance of the results but also the beta error and the detectable difference in
efficacy of the treatments. |
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| ISSN: | 0835-7900 |