Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention
ABSTRACT Objective: This study aimed to evaluate the impact of the Brazilian Cardioprotective Nutrition Program (BALANCE Program) on the plasma levels of various apolipoproteins (A-I, A-II, B, C-II, C-III, and E) and lipid biomarkers over a three-year follow-up period in individuals undergoing seco...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Brazilian Society of Endocrinology and Metabolism
2025-03-01
|
| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000101104&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186732091211776 |
|---|---|
| author | Aline Marcadenti Josefina Bressan Annie Seixas Bello Moreira Rachel Helena V. Machado Renato Hideo N. Santos Cristiane Kovacs Amaral Marcelo Macedo Rogero Vinícius Cooper Capetini Angela C. Bersch-Ferreira |
| author_facet | Aline Marcadenti Josefina Bressan Annie Seixas Bello Moreira Rachel Helena V. Machado Renato Hideo N. Santos Cristiane Kovacs Amaral Marcelo Macedo Rogero Vinícius Cooper Capetini Angela C. Bersch-Ferreira |
| author_sort | Aline Marcadenti |
| collection | DOAJ |
| description | ABSTRACT Objective: This study aimed to evaluate the impact of the Brazilian Cardioprotective Nutrition Program (BALANCE Program) on the plasma levels of various apolipoproteins (A-I, A-II, B, C-II, C-III, and E) and lipid biomarkers over a three-year follow-up period in individuals undergoing secondary cardiovascular prevention. Subjects and methods: This exploratory analysis included 276 patients aged 45 years or older with a history of cardiovascular disease within the preceding decade. Participants were randomly assigned to one of two groups and monitored over three years: the BALANCE Program group (intervention group; n = 123) and the control (conventional nutritional advice; n = 153). Assessments of clinical and lifestyle data, anthropometry, food intake, plasma apolipoproteins, and lipid profiles were conducted at baseline and at the 3-year follow-up. Intervention adherence was measured utilizing the BALANCE dietary index. Results: By the end of the follow-up period, adherence was significantly higher in the intervention group (mean difference BALANCE-control [95% CI]: 2.09 points [-0.19; 4.37]), mainly due to increased consumption of fruits, vegetables, legumes, and low-fat dairy products. There were no significant differences in plasma apolipoprotein levels between the groups throughout the study. Nevertheless, significant reductions were observed in the total cholesterol and non-HDL cholesterol levels in the BALANCE group compared to the control group (mean difference intervention-control [95% CI]: -9.95 mg/dL [-18.5; -1.39] and -8.86 mg/dL [-17.53; -0.2], respectively). Conclusion: Following three years of intervention, despite higher adherence to the BALANCE Program, there were no significant changes in plasma apolipoprotein concentrations or overall lipid biomarkers. |
| format | Article |
| id | doaj-art-1cccce0e0c8a4c5fa8b88c28aee072fe |
| institution | OA Journals |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-1cccce0e0c8a4c5fa8b88c28aee072fe2025-08-20T02:16:15ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-03-0169110.20945/2359-4292-2024-0373Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease preventionAline Marcadentihttps://orcid.org/0000-0003-1994-4610Josefina Bressanhttps://orcid.org/0000-0002-4993-9436Annie Seixas Bello Moreirahttps://orcid.org/0000-0002-3263-613XRachel Helena V. Machadohttps://orcid.org/0000-0001-6326-9144Renato Hideo N. Santoshttps://orcid.org/0000-0002-0650-212XCristiane Kovacs Amaralhttps://orcid.org/0000-0002-3575-0800Marcelo Macedo Rogerohttps://orcid.org/0000-0003-0517-1645Vinícius Cooper Capetinihttps://orcid.org/0000-0002-4724-8893Angela C. Bersch-Ferreirahttps://orcid.org/0000-0003-3478-781XABSTRACT Objective: This study aimed to evaluate the impact of the Brazilian Cardioprotective Nutrition Program (BALANCE Program) on the plasma levels of various apolipoproteins (A-I, A-II, B, C-II, C-III, and E) and lipid biomarkers over a three-year follow-up period in individuals undergoing secondary cardiovascular prevention. Subjects and methods: This exploratory analysis included 276 patients aged 45 years or older with a history of cardiovascular disease within the preceding decade. Participants were randomly assigned to one of two groups and monitored over three years: the BALANCE Program group (intervention group; n = 123) and the control (conventional nutritional advice; n = 153). Assessments of clinical and lifestyle data, anthropometry, food intake, plasma apolipoproteins, and lipid profiles were conducted at baseline and at the 3-year follow-up. Intervention adherence was measured utilizing the BALANCE dietary index. Results: By the end of the follow-up period, adherence was significantly higher in the intervention group (mean difference BALANCE-control [95% CI]: 2.09 points [-0.19; 4.37]), mainly due to increased consumption of fruits, vegetables, legumes, and low-fat dairy products. There were no significant differences in plasma apolipoprotein levels between the groups throughout the study. Nevertheless, significant reductions were observed in the total cholesterol and non-HDL cholesterol levels in the BALANCE group compared to the control group (mean difference intervention-control [95% CI]: -9.95 mg/dL [-18.5; -1.39] and -8.86 mg/dL [-17.53; -0.2], respectively). Conclusion: Following three years of intervention, despite higher adherence to the BALANCE Program, there were no significant changes in plasma apolipoprotein concentrations or overall lipid biomarkers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000101104&lng=en&tlng=enCardiovascular diseasessecondary preventionapolipoproteinsdiethealthy |
| spellingShingle | Aline Marcadenti Josefina Bressan Annie Seixas Bello Moreira Rachel Helena V. Machado Renato Hideo N. Santos Cristiane Kovacs Amaral Marcelo Macedo Rogero Vinícius Cooper Capetini Angela C. Bersch-Ferreira Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention Archives of Endocrinology and Metabolism Cardiovascular diseases secondary prevention apolipoproteins diet healthy |
| title | Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention |
| title_full | Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention |
| title_fullStr | Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention |
| title_full_unstemmed | Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention |
| title_short | Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention |
| title_sort | effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention |
| topic | Cardiovascular diseases secondary prevention apolipoproteins diet healthy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000101104&lng=en&tlng=en |
| work_keys_str_mv | AT alinemarcadenti effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT josefinabressan effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT annieseixasbellomoreira effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT rachelhelenavmachado effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT renatohideonsantos effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT cristianekovacsamaral effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT marcelomacedorogero effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT viniciuscoopercapetini effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention AT angelacberschferreira effectsofacardioprotectivenutritionalprogramonapolipoproteinsandlipidsinsecondarycardiovasculardiseaseprevention |