Neoadjuvant Treatment in Rectal Cancer

Neoadjuvant Treatment in Rectal Cancer

A major advance in rectal cancer was the evidence supporting short-course radiotherapy and long-course chemoradiotherapy. Both have been shown to improve local outcomes. Total neoadjuvant therapy (TNT) is the new kid on the block that provides further benefit of improving local responses as well as...

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Main Authors: Srinath Bhradwaj R., Aditya Sarin, Shyam Aggarwal, Shikha Halder, S. Hukku, Taha Mustafa, Vijay Arora, V.K. Malik, Shivendra Singh, G.V. Rao, Avinash Saklani, Rajesh Bhojwani, Saumitra Rawat, C. Selvasekar, Purvish M. Parikh
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2024-10-01
Series:South Asian Journal of Cancer
Subjects:
TNT
NOM
LCCRT
SCRT
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1802334
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Summary:A major advance in rectal cancer was the evidence supporting short-course radiotherapy and long-course chemoradiotherapy. Both have been shown to improve local outcomes. Total neoadjuvant therapy (TNT) is the new kid on the block that provides further benefit of improving local responses as well as reducing systemic relapses, thus increasing overall survival. Details of the four key TNT trials are discussed. They pave the way for nonoperative management for patients who achieve clinical complete responses.
ISSN:2278-330X
2278-4306

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