Strains of Rodents and the Pharmacology of Learning and Memory

Mendelian genetic tools have extensively been used to improve the description of the pharmacological mechanisms involved in learning and memory. The first part of this short review describes experiments involving the bidirectional selection of rats or mice for extreme behavioral characteristics or f...

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Main Authors: Martine Ammassari-Teule, Claudio Castellano
Format: Article
Language:English
Published: Wiley 2004-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/NP.2004.205
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author Martine Ammassari-Teule
Claudio Castellano
author_facet Martine Ammassari-Teule
Claudio Castellano
author_sort Martine Ammassari-Teule
collection DOAJ
description Mendelian genetic tools have extensively been used to improve the description of the pharmacological mechanisms involved in learning and memory. The first part of this short review describes experiments involving the bidirectional selection of rats or mice for extreme behavioral characteristics or for sensitivity to pharmacological treatments. The second part focuses specifically on inbreeding. In conclusion, the advantages and the limits of a Mendelian pharmacogenetic approach of learning and memory are discussed.
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spelling doaj-art-1cc07129c80d4282a81b370af1661b172025-02-03T00:59:20ZengWileyNeural Plasticity2090-59041687-54432004-01-01113-420521610.1155/NP.2004.205Strains of Rodents and the Pharmacology of Learning and MemoryMartine Ammassari-Teule0Claudio Castellano1CNR Institute of Neuroscience, Laboratory of Psychobiology and Psychopharmacology, Rome, ItalyCNR Institute of Neuroscience, Laboratory of Psychobiology and Psychopharmacology, Rome, ItalyMendelian genetic tools have extensively been used to improve the description of the pharmacological mechanisms involved in learning and memory. The first part of this short review describes experiments involving the bidirectional selection of rats or mice for extreme behavioral characteristics or for sensitivity to pharmacological treatments. The second part focuses specifically on inbreeding. In conclusion, the advantages and the limits of a Mendelian pharmacogenetic approach of learning and memory are discussed.http://dx.doi.org/10.1155/NP.2004.205
spellingShingle Martine Ammassari-Teule
Claudio Castellano
Strains of Rodents and the Pharmacology of Learning and Memory
Neural Plasticity
title Strains of Rodents and the Pharmacology of Learning and Memory
title_full Strains of Rodents and the Pharmacology of Learning and Memory
title_fullStr Strains of Rodents and the Pharmacology of Learning and Memory
title_full_unstemmed Strains of Rodents and the Pharmacology of Learning and Memory
title_short Strains of Rodents and the Pharmacology of Learning and Memory
title_sort strains of rodents and the pharmacology of learning and memory
url http://dx.doi.org/10.1155/NP.2004.205
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AT claudiocastellano strainsofrodentsandthepharmacologyoflearningandmemory