Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth
The pituitary gland (PG) plays a central role in the production and secretion of pubertal hormones, with documented links to the increase in mental health symptoms during adolescence. Although literature has largely focused on examining whole PG volume, recent findings have demonstrated associations...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929325000027 |
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| author | Giorgia Picci Nathan M. Petro Chloe C. Casagrande Lauren R. Ott Hannah J. Okelberry Danielle L. Rice Anna T. Coutant Grace C. Ende Erica L. Steiner Yu-Ping Wang Julia M. Stephen Vince D. Calhoun Tony W. Wilson |
| author_facet | Giorgia Picci Nathan M. Petro Chloe C. Casagrande Lauren R. Ott Hannah J. Okelberry Danielle L. Rice Anna T. Coutant Grace C. Ende Erica L. Steiner Yu-Ping Wang Julia M. Stephen Vince D. Calhoun Tony W. Wilson |
| author_sort | Giorgia Picci |
| collection | DOAJ |
| description | The pituitary gland (PG) plays a central role in the production and secretion of pubertal hormones, with documented links to the increase in mental health symptoms during adolescence. Although literature has largely focused on examining whole PG volume, recent findings have demonstrated associations among pubertal hormone levels, including dehydroepiandrosterone (DHEA), PG subregions, and mental health symptoms during adolescence. Despite the anterior PG’s role in DHEA production, studies have not yet examined potential links with transdiagnostic symptomology (i.e., dysregulation) pertinent to long-term functioning. Therefore, the current study sought examine whether anterior PG volume mediates associations between DHEA levels and changes in dysregulation symptoms in an adolescent sample (N = 114, 9 –17 years, Mage = 12.87, SD = 1.88). Following manual tracing, structural equation modeling revealed that greater anterior, not posterior, PG volume mediated the association between greater DHEA levels and increasing dysregulation symptoms across time, controlling for baseline dysregulation symptom levels. Results also showed that greater DHEA levels related to decreasing symptoms across time, suggesting potential attenuation effects. Altogether, these results provide support for separating the anterior and posterior PG by demonstrating specificity in the role of the anterior PG in adrenarcheal processes that may confer risk for adolescent psychopathology. |
| format | Article |
| id | doaj-art-1cbbfa60a53a40f0b213270b8ed35f4d |
| institution | Kabale University |
| issn | 1878-9293 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj-art-1cbbfa60a53a40f0b213270b8ed35f4d2025-01-22T05:41:21ZengElsevierDevelopmental Cognitive Neuroscience1878-92932025-01-0171101507Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youthGiorgia Picci0Nathan M. Petro1Chloe C. Casagrande2Lauren R. Ott3Hannah J. Okelberry4Danielle L. Rice5Anna T. Coutant6Grace C. Ende7Erica L. Steiner8Yu-Ping Wang9Julia M. Stephen10Vince D. Calhoun11Tony W. Wilson12Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA; Correspondence to: Research Scientist, Laboratory Director, Institute for Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Lane, Boys Town, NE, USA.Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USADepartment of Biomedical Engineering, Tulane University, New Orleans, LA, USAMind Research Network, Albuquerque, NM, USATri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, GA, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USAThe pituitary gland (PG) plays a central role in the production and secretion of pubertal hormones, with documented links to the increase in mental health symptoms during adolescence. Although literature has largely focused on examining whole PG volume, recent findings have demonstrated associations among pubertal hormone levels, including dehydroepiandrosterone (DHEA), PG subregions, and mental health symptoms during adolescence. Despite the anterior PG’s role in DHEA production, studies have not yet examined potential links with transdiagnostic symptomology (i.e., dysregulation) pertinent to long-term functioning. Therefore, the current study sought examine whether anterior PG volume mediates associations between DHEA levels and changes in dysregulation symptoms in an adolescent sample (N = 114, 9 –17 years, Mage = 12.87, SD = 1.88). Following manual tracing, structural equation modeling revealed that greater anterior, not posterior, PG volume mediated the association between greater DHEA levels and increasing dysregulation symptoms across time, controlling for baseline dysregulation symptom levels. Results also showed that greater DHEA levels related to decreasing symptoms across time, suggesting potential attenuation effects. Altogether, these results provide support for separating the anterior and posterior PG by demonstrating specificity in the role of the anterior PG in adrenarcheal processes that may confer risk for adolescent psychopathology.http://www.sciencedirect.com/science/article/pii/S1878929325000027PubertyPituitaryAdrenarcheBrain structureTransdiagnosticDHEA |
| spellingShingle | Giorgia Picci Nathan M. Petro Chloe C. Casagrande Lauren R. Ott Hannah J. Okelberry Danielle L. Rice Anna T. Coutant Grace C. Ende Erica L. Steiner Yu-Ping Wang Julia M. Stephen Vince D. Calhoun Tony W. Wilson Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth Developmental Cognitive Neuroscience Puberty Pituitary Adrenarche Brain structure Transdiagnostic DHEA |
| title | Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth |
| title_full | Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth |
| title_fullStr | Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth |
| title_full_unstemmed | Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth |
| title_short | Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth |
| title_sort | anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth |
| topic | Puberty Pituitary Adrenarche Brain structure Transdiagnostic DHEA |
| url | http://www.sciencedirect.com/science/article/pii/S1878929325000027 |
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