Cell cycle checkpoint factor p15Ink4b is a novel regulator of osteoclast differentiation

Abstract Osteoclasts are specialized cells essential for bone resorption, a crucial process in bone remodeling, and dysregulation of osteoclastogenesis can lead to pathological bone loss such as osteoporosis and rheumatoid arthritis. Therefore, understanding the precise mechanisms governing osteocla...

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Main Authors: Shunya Tsuji, Sora Mizukami, Akihiko Sakamoto, Kenji Takemoto, Tetsuya Seto, Kazuya Uehara, Kiminori Yukata, Takashi Sakai, Keiko Iwaisako, Norihiko Takeda, Ryoji Yanai, Masataka Asagiri
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-89988-w
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