Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with Dexmedetomidine
Midazolam is a widely used benzodiazepine due to its rapid onset of action and relatively safe side effect profile. It is used for sedation, anxiolysis, and induction of general anesthesia. However, in <1% of instances, it may cause a paradoxical excitement: agitation, restlessness, myoclonus, st...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Anesthesiology |
| Online Access: | http://dx.doi.org/10.1155/2024/4152422 |
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| author | Sarah Park Mariam Ibrahim Augusto Torres |
| author_facet | Sarah Park Mariam Ibrahim Augusto Torres |
| author_sort | Sarah Park |
| collection | DOAJ |
| description | Midazolam is a widely used benzodiazepine due to its rapid onset of action and relatively safe side effect profile. It is used for sedation, anxiolysis, and induction of general anesthesia. However, in <1% of instances, it may cause a paradoxical excitement: agitation, restlessness, myoclonus, stiffening of the limbs, and aggression. We report a case report in which preoperative administration of midazolam caused onset of the aforementioned symptoms that were not attenuated by general anesthesia with dexmedetomidine. This case report aims to create awareness about the rare adverse reactions of midazolam and prepare clinicians to manage these situations. |
| format | Article |
| id | doaj-art-1cb6f638e1e34df6b0ea1d9583ab4072 |
| institution | Kabale University |
| issn | 2090-6390 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Anesthesiology |
| spelling | doaj-art-1cb6f638e1e34df6b0ea1d9583ab40722025-02-03T01:29:50ZengWileyCase Reports in Anesthesiology2090-63902024-01-01202410.1155/2024/4152422Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with DexmedetomidineSarah Park0Mariam Ibrahim1Augusto Torres2Case Western Reserve University School of MedicineDepartment of AnesthesiologyDepartment of AnesthesiologyMidazolam is a widely used benzodiazepine due to its rapid onset of action and relatively safe side effect profile. It is used for sedation, anxiolysis, and induction of general anesthesia. However, in <1% of instances, it may cause a paradoxical excitement: agitation, restlessness, myoclonus, stiffening of the limbs, and aggression. We report a case report in which preoperative administration of midazolam caused onset of the aforementioned symptoms that were not attenuated by general anesthesia with dexmedetomidine. This case report aims to create awareness about the rare adverse reactions of midazolam and prepare clinicians to manage these situations.http://dx.doi.org/10.1155/2024/4152422 |
| spellingShingle | Sarah Park Mariam Ibrahim Augusto Torres Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with Dexmedetomidine Case Reports in Anesthesiology |
| title | Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with Dexmedetomidine |
| title_full | Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with Dexmedetomidine |
| title_fullStr | Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with Dexmedetomidine |
| title_full_unstemmed | Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with Dexmedetomidine |
| title_short | Persistent Paradoxical Reaction to Midazolam despite General Anesthesia with Dexmedetomidine |
| title_sort | persistent paradoxical reaction to midazolam despite general anesthesia with dexmedetomidine |
| url | http://dx.doi.org/10.1155/2024/4152422 |
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