Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach
Background: Studies regarding hypercoagulation in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) patients have produced conflicting results. With a presumption that the early coagulation phase may affect the occurrence of NAION, this study aims to investigate the early coagulation markers,...
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Interna Publishing
2024-10-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://actamedindones.org/index.php/ijim/article/view/2581 |
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| author | Syntia Nusanti Andhika Rachman Brigitta Marcia Budihardja Lourisa Ruth Eldinia Nadia Delima Andini Arief Kartasasmita M Sidik Seskoati Prayitnaningsih Alida Roswita Harahap Aria Kekalih Tjahjono Darminto Gondhowiardjo |
| author_facet | Syntia Nusanti Andhika Rachman Brigitta Marcia Budihardja Lourisa Ruth Eldinia Nadia Delima Andini Arief Kartasasmita M Sidik Seskoati Prayitnaningsih Alida Roswita Harahap Aria Kekalih Tjahjono Darminto Gondhowiardjo |
| author_sort | Syntia Nusanti |
| collection | DOAJ |
| description | Background: Studies regarding hypercoagulation in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) patients have produced conflicting results. With a presumption that the early coagulation phase may affect the occurrence of NAION, this study aims to investigate the early coagulation markers, E-selectin and P-selectin, to determine whether these biomolecular changes play a significant role in NAION, thus potentially leading to a better clinical approach. Methods: A cross-sectional study involving two groups of NAION subjects, a hypercoagulation group and a non-hypercoagulation group, was conducted in the Neuro-Ophthalmology Division, Department of Ophthalmology, FKUI-RSCM Kirana from October 2020 to April 2022. All patients were evaluated for E-selectin and P-selectin levels measured using flow cytometry. Results: A total of 42 subjects comprising 14 hypercoagulation and 28 non-hypercoagulation subjects were included. In all subjects, E-selectin was strongly correlated with P-selectin (r = 0.862, p < 0.001). There was no significant difference in E-selectin and P-selectin values between the groups (p = 0.317 for E-selectin, and p = 0.575 for P-selectin). Prothrombin time and international normalized ratio (INR) were inversely correlated with both E-selectin and P-selectin in the hypercoagulation group (p = 0.032, p = 0.030 for E-selectin and p = 0.044, p = 0.036 for P-selectin). There was no significant correlation between E-selectin and P-selectin for NAION-associated metabolic risk factors. However, higher E-selectin and P-selectin values were found in the presence of risk factors except for P-selectin in the hypertension group. Conclusion: This interesting finding opens up the potential for considering the involvement of E-selectin and P-selectin in the diagnostic strategy for NAION. It prompts consideration of whether assessing E-selectin and P-selectin levels should be recommended for all NAION patients. Furthermore, considering the role of E-selectin and P-selectin in the early coagulation process, future studies are also needed to further evaluate whether anticoagulants could play a role in the choice of treatment for NAION despite a clinically hypercoagulable state. |
| format | Article |
| id | doaj-art-1cb62b7793b34226a09833b8d09f46c9 |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Interna Publishing |
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| series | Acta Medica Indonesiana |
| spelling | doaj-art-1cb62b7793b34226a09833b8d09f46c92025-01-27T04:12:06ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322024-10-01564691Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical ApproachSyntia Nusanti0Andhika Rachman1Brigitta Marcia Budihardja2Lourisa Ruth Eldinia3Nadia Delima Andini4Arief Kartasasmita5M Sidik6Seskoati Prayitnaningsih7Alida Roswita Harahap8Aria Kekalih9Tjahjono Darminto Gondhowiardjo101. Doctoral Program in Medical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. 2. Neuro-ophthalmology Division, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, IndonesiaResidency Program in Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, IndonesiaResidency Program in Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, IndonesiaResearch Assistant, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, IndonesiaVitreoretina Division, Department of Ophthalmology, Faculty of Medicine Padjajaran University – Cicendo Eye Hospital, Bandung, IndonesiaNeuro-ophthalmology Division, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Neuro-ophthalmology Division, Department of Ophthalmology, Faculty of Medicine Brawijaya University –Saiful Anwar General Hospital, Malang, IndonesiaDoctoral Program in Medical Science, Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaDepartment of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.1. Doctoral Program in Medical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. 2. Cataract and Refractive Surgery Division, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Background: Studies regarding hypercoagulation in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) patients have produced conflicting results. With a presumption that the early coagulation phase may affect the occurrence of NAION, this study aims to investigate the early coagulation markers, E-selectin and P-selectin, to determine whether these biomolecular changes play a significant role in NAION, thus potentially leading to a better clinical approach. Methods: A cross-sectional study involving two groups of NAION subjects, a hypercoagulation group and a non-hypercoagulation group, was conducted in the Neuro-Ophthalmology Division, Department of Ophthalmology, FKUI-RSCM Kirana from October 2020 to April 2022. All patients were evaluated for E-selectin and P-selectin levels measured using flow cytometry. Results: A total of 42 subjects comprising 14 hypercoagulation and 28 non-hypercoagulation subjects were included. In all subjects, E-selectin was strongly correlated with P-selectin (r = 0.862, p < 0.001). There was no significant difference in E-selectin and P-selectin values between the groups (p = 0.317 for E-selectin, and p = 0.575 for P-selectin). Prothrombin time and international normalized ratio (INR) were inversely correlated with both E-selectin and P-selectin in the hypercoagulation group (p = 0.032, p = 0.030 for E-selectin and p = 0.044, p = 0.036 for P-selectin). There was no significant correlation between E-selectin and P-selectin for NAION-associated metabolic risk factors. However, higher E-selectin and P-selectin values were found in the presence of risk factors except for P-selectin in the hypertension group. Conclusion: This interesting finding opens up the potential for considering the involvement of E-selectin and P-selectin in the diagnostic strategy for NAION. It prompts consideration of whether assessing E-selectin and P-selectin levels should be recommended for all NAION patients. Furthermore, considering the role of E-selectin and P-selectin in the early coagulation process, future studies are also needed to further evaluate whether anticoagulants could play a role in the choice of treatment for NAION despite a clinically hypercoagulable state.https://actamedindones.org/index.php/ijim/article/view/2581non-arteritic anterior ischemic optic neuropathynaione-selectinp-selectinhypercoagulation |
| spellingShingle | Syntia Nusanti Andhika Rachman Brigitta Marcia Budihardja Lourisa Ruth Eldinia Nadia Delima Andini Arief Kartasasmita M Sidik Seskoati Prayitnaningsih Alida Roswita Harahap Aria Kekalih Tjahjono Darminto Gondhowiardjo Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach Acta Medica Indonesiana non-arteritic anterior ischemic optic neuropathy naion e-selectin p-selectin hypercoagulation |
| title | Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach |
| title_full | Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach |
| title_fullStr | Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach |
| title_full_unstemmed | Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach |
| title_short | Investigating Elevated E-Selectin and P-Selectin Levels in Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Patients: The Stepping Stone to a Future Clinical Approach |
| title_sort | investigating elevated e selectin and p selectin levels in non arteritic anterior ischemic optic neuropathy naion patients the stepping stone to a future clinical approach |
| topic | non-arteritic anterior ischemic optic neuropathy naion e-selectin p-selectin hypercoagulation |
| url | https://actamedindones.org/index.php/ijim/article/view/2581 |
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