Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
Throughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond timing of action potential firing (STDP). The sig...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/870763 |
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| author | Matthijs B. Verhoog Huibert D. Mansvelder |
| author_facet | Matthijs B. Verhoog Huibert D. Mansvelder |
| author_sort | Matthijs B. Verhoog |
| collection | DOAJ |
| description | Throughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond timing of action potential firing (STDP). The sign of synaptic plasticity depends on the spike order of presynaptic and postsynaptic neurons. Ionotropic neurotransmitter receptors, such as NMDA receptors and nicotinic acetylcholine receptors, are intimately involved in setting the rules for synaptic strengthening and weakening. In addition, timing rules for STDP within synapses are not fixed. They can be altered by activation of ionotropic receptors located at, or close to, synapses. Here, we will highlight studies that uncovered how network actions control and modulate timing rules for STDP by activating presynaptic ionotropic receptors. Furthermore, we will discuss how interaction between different types of ionotropic receptors may create “timing” windows during which particular timing rules lead to synaptic changes. |
| format | Article |
| id | doaj-art-1cb590651a4d4a31b6e39074a60ffeac |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-1cb590651a4d4a31b6e39074a60ffeac2025-02-03T07:26:09ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/870763870763Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent PlasticityMatthijs B. Verhoog0Huibert D. Mansvelder1Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University Amsterdam, Room C-440, De Boelelaan 1085, 1081 HV Amsterdam, The NetherlandsDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University Amsterdam, Room C-440, De Boelelaan 1085, 1081 HV Amsterdam, The NetherlandsThroughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond timing of action potential firing (STDP). The sign of synaptic plasticity depends on the spike order of presynaptic and postsynaptic neurons. Ionotropic neurotransmitter receptors, such as NMDA receptors and nicotinic acetylcholine receptors, are intimately involved in setting the rules for synaptic strengthening and weakening. In addition, timing rules for STDP within synapses are not fixed. They can be altered by activation of ionotropic receptors located at, or close to, synapses. Here, we will highlight studies that uncovered how network actions control and modulate timing rules for STDP by activating presynaptic ionotropic receptors. Furthermore, we will discuss how interaction between different types of ionotropic receptors may create “timing” windows during which particular timing rules lead to synaptic changes.http://dx.doi.org/10.1155/2011/870763 |
| spellingShingle | Matthijs B. Verhoog Huibert D. Mansvelder Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity Neural Plasticity |
| title | Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity |
| title_full | Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity |
| title_fullStr | Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity |
| title_full_unstemmed | Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity |
| title_short | Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity |
| title_sort | presynaptic ionotropic receptors controlling and modulating the rules for spike timing dependent plasticity |
| url | http://dx.doi.org/10.1155/2011/870763 |
| work_keys_str_mv | AT matthijsbverhoog presynapticionotropicreceptorscontrollingandmodulatingtherulesforspiketimingdependentplasticity AT huibertdmansvelder presynapticionotropicreceptorscontrollingandmodulatingtherulesforspiketimingdependentplasticity |