Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity

Throughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond timing of action potential firing (STDP). The sig...

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Main Authors: Matthijs B. Verhoog, Huibert D. Mansvelder
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2011/870763
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author Matthijs B. Verhoog
Huibert D. Mansvelder
author_facet Matthijs B. Verhoog
Huibert D. Mansvelder
author_sort Matthijs B. Verhoog
collection DOAJ
description Throughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond timing of action potential firing (STDP). The sign of synaptic plasticity depends on the spike order of presynaptic and postsynaptic neurons. Ionotropic neurotransmitter receptors, such as NMDA receptors and nicotinic acetylcholine receptors, are intimately involved in setting the rules for synaptic strengthening and weakening. In addition, timing rules for STDP within synapses are not fixed. They can be altered by activation of ionotropic receptors located at, or close to, synapses. Here, we will highlight studies that uncovered how network actions control and modulate timing rules for STDP by activating presynaptic ionotropic receptors. Furthermore, we will discuss how interaction between different types of ionotropic receptors may create “timing” windows during which particular timing rules lead to synaptic changes.
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spelling doaj-art-1cb590651a4d4a31b6e39074a60ffeac2025-02-03T07:26:09ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/870763870763Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent PlasticityMatthijs B. Verhoog0Huibert D. Mansvelder1Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University Amsterdam, Room C-440, De Boelelaan 1085, 1081 HV Amsterdam, The NetherlandsDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University Amsterdam, Room C-440, De Boelelaan 1085, 1081 HV Amsterdam, The NetherlandsThroughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. In line with predictions made by Hebb, synapse strength can be modified depending on the millisecond timing of action potential firing (STDP). The sign of synaptic plasticity depends on the spike order of presynaptic and postsynaptic neurons. Ionotropic neurotransmitter receptors, such as NMDA receptors and nicotinic acetylcholine receptors, are intimately involved in setting the rules for synaptic strengthening and weakening. In addition, timing rules for STDP within synapses are not fixed. They can be altered by activation of ionotropic receptors located at, or close to, synapses. Here, we will highlight studies that uncovered how network actions control and modulate timing rules for STDP by activating presynaptic ionotropic receptors. Furthermore, we will discuss how interaction between different types of ionotropic receptors may create “timing” windows during which particular timing rules lead to synaptic changes.http://dx.doi.org/10.1155/2011/870763
spellingShingle Matthijs B. Verhoog
Huibert D. Mansvelder
Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
Neural Plasticity
title Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
title_full Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
title_fullStr Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
title_full_unstemmed Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
title_short Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
title_sort presynaptic ionotropic receptors controlling and modulating the rules for spike timing dependent plasticity
url http://dx.doi.org/10.1155/2011/870763
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