Prioritization of delayed vaccination for pandemic influenza
Limited production capacity and delays in vaccine development aremajor obstacles to vaccination programs that are designed tomitigate a pandemic influenza. In order to evaluate and compare theimpact of various vaccination strategies during a pandemic influenza, we developed an age/risk-structured mo...
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| Format: | Article |
| Language: | English |
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AIMS Press
2010-12-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.95 |
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| _version_ | 1832590169986826240 |
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| author | Eunha Shim |
| author_facet | Eunha Shim |
| author_sort | Eunha Shim |
| collection | DOAJ |
| description | Limited production capacity and delays in vaccine development aremajor obstacles to vaccination programs that are designed tomitigate a pandemic influenza. In order to evaluate and compare theimpact of various vaccination strategies during a pandemic influenza, we developed an age/risk-structured model of influenzatransmission, and parameterized it with epidemiological data fromthe 2009 H1N1 influenza A pandemic. Our model predicts that theimpact of vaccination would be considerably diminished by delays invaccination and staggered vaccine supply. Nonetheless, prioritizing limited H1N1 vaccine toindividuals with a high risk of complications, followed byschool-age children, and then preschool-age children, would minimizean overall attack rate as well as hospitalizations anddeaths. This vaccination scheme would maximize the benefits ofvaccination by protecting the high-risk people directly, andgenerating indirect protection by vaccinating children who are mostlikely to transmit the disease. |
| format | Article |
| id | doaj-art-1caa655014494d07ba836df3e2f7736d |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2010-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-1caa655014494d07ba836df3e2f7736d2025-01-24T02:01:20ZengAIMS PressMathematical Biosciences and Engineering1551-00182010-12-01819511210.3934/mbe.2011.8.95Prioritization of delayed vaccination for pandemic influenzaEunha Shim0Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261Limited production capacity and delays in vaccine development aremajor obstacles to vaccination programs that are designed tomitigate a pandemic influenza. In order to evaluate and compare theimpact of various vaccination strategies during a pandemic influenza, we developed an age/risk-structured model of influenzatransmission, and parameterized it with epidemiological data fromthe 2009 H1N1 influenza A pandemic. Our model predicts that theimpact of vaccination would be considerably diminished by delays invaccination and staggered vaccine supply. Nonetheless, prioritizing limited H1N1 vaccine toindividuals with a high risk of complications, followed byschool-age children, and then preschool-age children, would minimizean overall attack rate as well as hospitalizations anddeaths. This vaccination scheme would maximize the benefits ofvaccination by protecting the high-risk people directly, andgenerating indirect protection by vaccinating children who are mostlikely to transmit the disease.https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.95optimalpandemicdelayinfluenzavaccinationh1n1. |
| spellingShingle | Eunha Shim Prioritization of delayed vaccination for pandemic influenza Mathematical Biosciences and Engineering optimal pandemic delay influenza vaccination h1n1. |
| title | Prioritization of delayed vaccination for pandemic influenza |
| title_full | Prioritization of delayed vaccination for pandemic influenza |
| title_fullStr | Prioritization of delayed vaccination for pandemic influenza |
| title_full_unstemmed | Prioritization of delayed vaccination for pandemic influenza |
| title_short | Prioritization of delayed vaccination for pandemic influenza |
| title_sort | prioritization of delayed vaccination for pandemic influenza |
| topic | optimal pandemic delay influenza vaccination h1n1. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.95 |
| work_keys_str_mv | AT eunhashim prioritizationofdelayedvaccinationforpandemicinfluenza |