Prioritization of delayed vaccination for pandemic influenza
Limited production capacity and delays in vaccine development aremajor obstacles to vaccination programs that are designed tomitigate a pandemic influenza. In order to evaluate and compare theimpact of various vaccination strategies during a pandemic influenza, we developed an age/risk-structured mo...
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| Format: | Article |
| Language: | English |
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AIMS Press
2010-12-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.95 |
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| Summary: | Limited production capacity and delays in vaccine development aremajor obstacles to vaccination programs that are designed tomitigate a pandemic influenza. In order to evaluate and compare theimpact of various vaccination strategies during a pandemic influenza, we developed an age/risk-structured model of influenzatransmission, and parameterized it with epidemiological data fromthe 2009 H1N1 influenza A pandemic. Our model predicts that theimpact of vaccination would be considerably diminished by delays invaccination and staggered vaccine supply. Nonetheless, prioritizing limited H1N1 vaccine toindividuals with a high risk of complications, followed byschool-age children, and then preschool-age children, would minimizean overall attack rate as well as hospitalizations anddeaths. This vaccination scheme would maximize the benefits ofvaccination by protecting the high-risk people directly, andgenerating indirect protection by vaccinating children who are mostlikely to transmit the disease. |
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| ISSN: | 1551-0018 |