Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice
Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01,...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/951210 |
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| _version_ | 1832550259754008576 |
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| author | Ling-ling Zhou Wei Wei Jun-feng Si Dong-ping Yuan |
| author_facet | Ling-ling Zhou Wei Wei Jun-feng Si Dong-ping Yuan |
| author_sort | Ling-ling Zhou |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances. |
| format | Article |
| id | doaj-art-1c92a765a4a94f449dd6d59fa5cede64 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1c92a765a4a94f449dd6d59fa5cede642025-02-03T06:07:06ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/951210951210Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus MiceLing-ling Zhou0Wei Wei1Jun-feng Si2Dong-ping Yuan3Key Laboratory of Anti-inflammatory and immunopharmacology in Education Ministry of China, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, ChinaKey Laboratory of Anti-inflammatory and immunopharmacology in Education Ministry of China, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, ChinaInstitute for Biomedical Electronic Engineering, Nanjing University, Nanjing 210093, ChinaJiangsu Provincial Key Laboratory of Pharmacology and Safety Evaluation of Material Medica, Department of pharmacology, Nanjing University of Traditional Chinese Medicine, No. 282 Hanzhong Road, Nanjing 210029, ChinaSystemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.http://dx.doi.org/10.1155/2010/951210 |
| spellingShingle | Ling-ling Zhou Wei Wei Jun-feng Si Dong-ping Yuan Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice Mediators of Inflammation |
| title | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
| title_full | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
| title_fullStr | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
| title_full_unstemmed | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
| title_short | Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice |
| title_sort | regulatory effect of melatonin on cytokine disturbances in the pristane induced lupus mice |
| url | http://dx.doi.org/10.1155/2010/951210 |
| work_keys_str_mv | AT linglingzhou regulatoryeffectofmelatoninoncytokinedisturbancesinthepristaneinducedlupusmice AT weiwei regulatoryeffectofmelatoninoncytokinedisturbancesinthepristaneinducedlupusmice AT junfengsi regulatoryeffectofmelatoninoncytokinedisturbancesinthepristaneinducedlupusmice AT dongpingyuan regulatoryeffectofmelatoninoncytokinedisturbancesinthepristaneinducedlupusmice |