Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats
Objective. Fibrates are used as lipid-lowering drugs and are well tolerated as cotreatments when glucose metabolism disturbances are also present. Synthetic glucocorticoids (GCs) are diabetogenic drugs that cause dyslipidemia, dysglycemia, glucose intolerance, and insulin resistance when in excess....
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/3257812 |
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| author | Maiara Destro Inácio Alex Rafacho Nathália Aparecida de Paula Camaforte Poliana Teixeira Priscilla Maria Ponce Vareda Natália Moretti Violato José Roberto Bosqueiro |
| author_facet | Maiara Destro Inácio Alex Rafacho Nathália Aparecida de Paula Camaforte Poliana Teixeira Priscilla Maria Ponce Vareda Natália Moretti Violato José Roberto Bosqueiro |
| author_sort | Maiara Destro Inácio |
| collection | DOAJ |
| description | Objective. Fibrates are used as lipid-lowering drugs and are well tolerated as cotreatments when glucose metabolism disturbances are also present. Synthetic glucocorticoids (GCs) are diabetogenic drugs that cause dyslipidemia, dysglycemia, glucose intolerance, and insulin resistance when in excess. Thus, we aimed to describe the potential of bezafibrate in preventing or attenuating the adverse effects of GCs on glucose and lipid homeostasis. Methods. Male Wistar rats were treated with high-dose bezafibrate (300 mg/kg, body mass (b.m.)) daily for 28 consecutive days. In the last five days, the rats were also treated with dexamethasone (1 mg/kg, b.m.). Results. Dexamethasone treatment reduced the body mass gain and food intake, and bezafibrate treatment exerted no impact on these parameters. GC treatment caused an augmentation in fasting and fed glycemia, plasma triacylglycerol and nonesterified fatty acids, and insulinemia, and bezafibrate treatment completely prevented the elevation in plasma triacylglycerol and attenuated all other parameters. Insulin resistance and glucose intolerance induced by GC treatment were abolished and attenuated, respectively, by bezafibrate treatment. Conclusion. High-dose bezafibrate treatment prevents the increase in plasma triacylglycerol and the development of insulin resistance and attenuates glucose intolerance in rats caused by GC treatment, indicating the involvement of dyslipidemia in the GC-induced insulin resistance. |
| format | Article |
| id | doaj-art-1c8f83b1a7e541aeb0e9a5dc86f85df3 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1c8f83b1a7e541aeb0e9a5dc86f85df32025-02-03T01:13:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/32578123257812Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in RatsMaiara Destro Inácio0Alex Rafacho1Nathália Aparecida de Paula Camaforte2Poliana Teixeira3Priscilla Maria Ponce Vareda4Natália Moretti Violato5José Roberto Bosqueiro6Institute of Biosciences, São Paulo State University–UNESP, Botucatu, SP, BrazilDepartment of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina–UFSC, Florianópolis, SC, BrazilInstitute of Biosciences, São Paulo State University–UNESP, Botucatu, SP, BrazilInstitute of Biosciences, São Paulo State University–UNESP, Botucatu, SP, BrazilInstitute of Biosciences, São Paulo State University–UNESP, Botucatu, SP, BrazilInstitute of Biosciences, São Paulo State University–UNESP, Botucatu, SP, BrazilDepartment of Physical Education, Faculty of Sciences, São Paulo State University–UNESP, Bauru, SP, BrazilObjective. Fibrates are used as lipid-lowering drugs and are well tolerated as cotreatments when glucose metabolism disturbances are also present. Synthetic glucocorticoids (GCs) are diabetogenic drugs that cause dyslipidemia, dysglycemia, glucose intolerance, and insulin resistance when in excess. Thus, we aimed to describe the potential of bezafibrate in preventing or attenuating the adverse effects of GCs on glucose and lipid homeostasis. Methods. Male Wistar rats were treated with high-dose bezafibrate (300 mg/kg, body mass (b.m.)) daily for 28 consecutive days. In the last five days, the rats were also treated with dexamethasone (1 mg/kg, b.m.). Results. Dexamethasone treatment reduced the body mass gain and food intake, and bezafibrate treatment exerted no impact on these parameters. GC treatment caused an augmentation in fasting and fed glycemia, plasma triacylglycerol and nonesterified fatty acids, and insulinemia, and bezafibrate treatment completely prevented the elevation in plasma triacylglycerol and attenuated all other parameters. Insulin resistance and glucose intolerance induced by GC treatment were abolished and attenuated, respectively, by bezafibrate treatment. Conclusion. High-dose bezafibrate treatment prevents the increase in plasma triacylglycerol and the development of insulin resistance and attenuates glucose intolerance in rats caused by GC treatment, indicating the involvement of dyslipidemia in the GC-induced insulin resistance.http://dx.doi.org/10.1155/2018/3257812 |
| spellingShingle | Maiara Destro Inácio Alex Rafacho Nathália Aparecida de Paula Camaforte Poliana Teixeira Priscilla Maria Ponce Vareda Natália Moretti Violato José Roberto Bosqueiro Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats International Journal of Endocrinology |
| title | Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats |
| title_full | Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats |
| title_fullStr | Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats |
| title_full_unstemmed | Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats |
| title_short | Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatment with Dexamethasone in Rats |
| title_sort | prevention of elevation in plasma triacylglycerol with high dose bezafibrate treatment abolishes insulin resistance and attenuates glucose intolerance induced by short term treatment with dexamethasone in rats |
| url | http://dx.doi.org/10.1155/2018/3257812 |
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