Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review

        Sulfamethoxazole and its derivatives are commonly utilized in the pharmaceutical and medicinal industry due to their biological and pharmaceutical activities, including anti-tubercular, anti-fungal, anti-cancer, anti-bacterial, and herbicidal activities. This review presents the latest an...

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Main Authors: Laith Jumaah Al-Gburi, Taghreed H. Al-Noor, Eid Ahmed Abdalrazaq
Format: Article
Language:English
Published: University of Baghdad 2025-01-01
Series:Ibn Al-Haitham Journal for Pure and Applied Sciences
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Online Access:https://jih.uobaghdad.edu.iq/index.php/j/article/view/3091
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author Laith Jumaah Al-Gburi
Taghreed H. Al-Noor
Eid Ahmed Abdalrazaq
author_facet Laith Jumaah Al-Gburi
Taghreed H. Al-Noor
Eid Ahmed Abdalrazaq
author_sort Laith Jumaah Al-Gburi
collection DOAJ
description         Sulfamethoxazole and its derivatives are commonly utilized in the pharmaceutical and medicinal industry due to their biological and pharmaceutical activities, including anti-tubercular, anti-fungal, anti-cancer, anti-bacterial, and herbicidal activities. This review presents the latest and most promising studies related to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes and the biological activity associated with these complexes. Some organic drugs, including sulfamethoxazole, exhibit toxicological and pharmacological properties that can be administered in the form of metal complexes. Many researchers have synthesized organic ligands derived from sulfamethoxazole in the forms of Schiff bases and azo compounds, which exhibited higher biological and industrial properties when compared to sulfamethoxazole alone. One of the essential features that make Schiff base more desirable when used for coordination complexation is that it possesses the ability to coordinate with the metal ions via forming chelating; ring makes them very effective in clinical and analytical applications and represent the latest and most promising studies and relate to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes, as well as the biological activity associated with these complexes.
format Article
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institution Kabale University
issn 1609-4042
2521-3407
language English
publishDate 2025-01-01
publisher University of Baghdad
record_format Article
series Ibn Al-Haitham Journal for Pure and Applied Sciences
spelling doaj-art-1c8ca31ccd444b858bc86e25e6a432572025-01-22T01:21:10ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072025-01-0138110.30526/37.1.3091Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature ReviewLaith Jumaah Al-Gburi0https://orcid.org/0009-0004-5378-4002Taghreed H. Al-Noor1https://orcid.org/0000-0002-6761-7131Eid Ahmed Abdalrazaq2https://orcid.org/0000-0002-0836-7291Department of Chemistry, College of Education for Pure Science (Ibn-Al Haitham), University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Education for Pure Science (Ibn-Al Haitham), University of Baghdad, Baghdad, Iraq.Department of Chemistry, Faculty of Science, Al-Hussein Bin Talal University, Ma'an, Jordan.         Sulfamethoxazole and its derivatives are commonly utilized in the pharmaceutical and medicinal industry due to their biological and pharmaceutical activities, including anti-tubercular, anti-fungal, anti-cancer, anti-bacterial, and herbicidal activities. This review presents the latest and most promising studies related to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes and the biological activity associated with these complexes. Some organic drugs, including sulfamethoxazole, exhibit toxicological and pharmacological properties that can be administered in the form of metal complexes. Many researchers have synthesized organic ligands derived from sulfamethoxazole in the forms of Schiff bases and azo compounds, which exhibited higher biological and industrial properties when compared to sulfamethoxazole alone. One of the essential features that make Schiff base more desirable when used for coordination complexation is that it possesses the ability to coordinate with the metal ions via forming chelating; ring makes them very effective in clinical and analytical applications and represent the latest and most promising studies and relate to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes, as well as the biological activity associated with these complexes. https://jih.uobaghdad.edu.iq/index.php/j/article/view/3091Sulfamethoxazolemetal-complexessulfa-drugcoordination chemistry
spellingShingle Laith Jumaah Al-Gburi
Taghreed H. Al-Noor
Eid Ahmed Abdalrazaq
Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review
Ibn Al-Haitham Journal for Pure and Applied Sciences
Sulfamethoxazole
metal-complexes
sulfa-drug
coordination chemistry
title Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review
title_full Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review
title_fullStr Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review
title_full_unstemmed Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review
title_short Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review
title_sort biological activity of metal complexes of sulfamethoxazole and its derivatives a literature review
topic Sulfamethoxazole
metal-complexes
sulfa-drug
coordination chemistry
url https://jih.uobaghdad.edu.iq/index.php/j/article/view/3091
work_keys_str_mv AT laithjumaahalgburi biologicalactivityofmetalcomplexesofsulfamethoxazoleanditsderivativesaliteraturereview
AT taghreedhalnoor biologicalactivityofmetalcomplexesofsulfamethoxazoleanditsderivativesaliteraturereview
AT eidahmedabdalrazaq biologicalactivityofmetalcomplexesofsulfamethoxazoleanditsderivativesaliteraturereview