Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review
Sulfamethoxazole and its derivatives are commonly utilized in the pharmaceutical and medicinal industry due to their biological and pharmaceutical activities, including anti-tubercular, anti-fungal, anti-cancer, anti-bacterial, and herbicidal activities. This review presents the latest an...
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| Language: | English |
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University of Baghdad
2025-01-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
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| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3091 |
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| author | Laith Jumaah Al-Gburi Taghreed H. Al-Noor Eid Ahmed Abdalrazaq |
| author_facet | Laith Jumaah Al-Gburi Taghreed H. Al-Noor Eid Ahmed Abdalrazaq |
| author_sort | Laith Jumaah Al-Gburi |
| collection | DOAJ |
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Sulfamethoxazole and its derivatives are commonly utilized in the pharmaceutical and medicinal industry due to their biological and pharmaceutical activities, including anti-tubercular, anti-fungal, anti-cancer, anti-bacterial, and herbicidal activities. This review presents the latest and most promising studies related to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes and the biological activity associated with these complexes. Some organic drugs, including sulfamethoxazole, exhibit toxicological and pharmacological properties that can be administered in the form of metal complexes. Many researchers have synthesized organic ligands derived from sulfamethoxazole in the forms of Schiff bases and azo compounds, which exhibited higher biological and industrial properties when compared to sulfamethoxazole alone. One of the essential features that make Schiff base more desirable when used for coordination complexation is that it possesses the ability to coordinate with the metal ions via forming chelating; ring makes them very effective in clinical and analytical applications and represent the latest and most promising studies and relate to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes, as well as the biological activity associated with these complexes.
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| format | Article |
| id | doaj-art-1c8ca31ccd444b858bc86e25e6a43257 |
| institution | Kabale University |
| issn | 1609-4042 2521-3407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj-art-1c8ca31ccd444b858bc86e25e6a432572025-01-22T01:21:10ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072025-01-0138110.30526/37.1.3091Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature ReviewLaith Jumaah Al-Gburi0https://orcid.org/0009-0004-5378-4002Taghreed H. Al-Noor1https://orcid.org/0000-0002-6761-7131Eid Ahmed Abdalrazaq2https://orcid.org/0000-0002-0836-7291Department of Chemistry, College of Education for Pure Science (Ibn-Al Haitham), University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Education for Pure Science (Ibn-Al Haitham), University of Baghdad, Baghdad, Iraq.Department of Chemistry, Faculty of Science, Al-Hussein Bin Talal University, Ma'an, Jordan. Sulfamethoxazole and its derivatives are commonly utilized in the pharmaceutical and medicinal industry due to their biological and pharmaceutical activities, including anti-tubercular, anti-fungal, anti-cancer, anti-bacterial, and herbicidal activities. This review presents the latest and most promising studies related to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes and the biological activity associated with these complexes. Some organic drugs, including sulfamethoxazole, exhibit toxicological and pharmacological properties that can be administered in the form of metal complexes. Many researchers have synthesized organic ligands derived from sulfamethoxazole in the forms of Schiff bases and azo compounds, which exhibited higher biological and industrial properties when compared to sulfamethoxazole alone. One of the essential features that make Schiff base more desirable when used for coordination complexation is that it possesses the ability to coordinate with the metal ions via forming chelating; ring makes them very effective in clinical and analytical applications and represent the latest and most promising studies and relate to synthesizing organic derivatives of sulfamethoxazole and their drug-metal complexes, as well as the biological activity associated with these complexes. https://jih.uobaghdad.edu.iq/index.php/j/article/view/3091Sulfamethoxazolemetal-complexessulfa-drugcoordination chemistry |
| spellingShingle | Laith Jumaah Al-Gburi Taghreed H. Al-Noor Eid Ahmed Abdalrazaq Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review Ibn Al-Haitham Journal for Pure and Applied Sciences Sulfamethoxazole metal-complexes sulfa-drug coordination chemistry |
| title | Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review |
| title_full | Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review |
| title_fullStr | Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review |
| title_full_unstemmed | Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review |
| title_short | Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review |
| title_sort | biological activity of metal complexes of sulfamethoxazole and its derivatives a literature review |
| topic | Sulfamethoxazole metal-complexes sulfa-drug coordination chemistry |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3091 |
| work_keys_str_mv | AT laithjumaahalgburi biologicalactivityofmetalcomplexesofsulfamethoxazoleanditsderivativesaliteraturereview AT taghreedhalnoor biologicalactivityofmetalcomplexesofsulfamethoxazoleanditsderivativesaliteraturereview AT eidahmedabdalrazaq biologicalactivityofmetalcomplexesofsulfamethoxazoleanditsderivativesaliteraturereview |