Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case Report
Si-Ning Wang,* Yi-Zhou Lu,* Yujuan Zhao, Wei Cao, Rui-Li Zhang Department of Dermatology, The Second Affiliated Hospital Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: R...
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Dove Medical Press
2025-01-01
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| Series: | International Medical Case Reports Journal |
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| Online Access: | https://www.dovepress.com/intralesional-spesolimab-a-novel-and-effective-approach-for-palmoplant-peer-reviewed-fulltext-article-IMCRJ |
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| author | Wang SN Lu YZ Zhao Y Cao W Zhang RL |
| author_facet | Wang SN Lu YZ Zhao Y Cao W Zhang RL |
| author_sort | Wang SN |
| collection | DOAJ |
| description | Si-Ning Wang,* Yi-Zhou Lu,* Yujuan Zhao, Wei Cao, Rui-Li Zhang Department of Dermatology, The Second Affiliated Hospital Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rui-Li Zhang, Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, 210003, People’s Republic of China, Email rellyzhang@njmu.edu.cnAbstract: Palmoplantar pustulosis (PPP) is a chronic condition characterized by the presence of sterile pustules on the palms and soles of the feet. As we all know, there is currently no gold standard for the treatment of this intractable disease. Currently, interleukin-36 receptor (IL-36R)-targeted biologics are emerging as promising treatments for PPP. Here, we were the first to report a Chinese male with PPP who received an intralesional injection of spesolimab. We found that only a small intralesional injection volume of spesolimab could effectively suppress PPP in this case.Keywords: Palmoplantar pustulosis, spesolimab, intralesional injection, case report |
| format | Article |
| id | doaj-art-1c860091e112406086aa36da48e8ec04 |
| institution | Kabale University |
| issn | 1179-142X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj-art-1c860091e112406086aa36da48e8ec042025-01-30T18:07:17ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2025-01-01Volume 1820520999724Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case ReportWang SNLu YZZhao YCao WZhang RLSi-Ning Wang,* Yi-Zhou Lu,* Yujuan Zhao, Wei Cao, Rui-Li Zhang Department of Dermatology, The Second Affiliated Hospital Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rui-Li Zhang, Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, 210003, People’s Republic of China, Email rellyzhang@njmu.edu.cnAbstract: Palmoplantar pustulosis (PPP) is a chronic condition characterized by the presence of sterile pustules on the palms and soles of the feet. As we all know, there is currently no gold standard for the treatment of this intractable disease. Currently, interleukin-36 receptor (IL-36R)-targeted biologics are emerging as promising treatments for PPP. Here, we were the first to report a Chinese male with PPP who received an intralesional injection of spesolimab. We found that only a small intralesional injection volume of spesolimab could effectively suppress PPP in this case.Keywords: Palmoplantar pustulosis, spesolimab, intralesional injection, case reporthttps://www.dovepress.com/intralesional-spesolimab-a-novel-and-effective-approach-for-palmoplant-peer-reviewed-fulltext-article-IMCRJpalmoplantar pustulosisspesolimabintralesional injectioncase report |
| spellingShingle | Wang SN Lu YZ Zhao Y Cao W Zhang RL Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case Report International Medical Case Reports Journal palmoplantar pustulosis spesolimab intralesional injection case report |
| title | Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case Report |
| title_full | Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case Report |
| title_fullStr | Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case Report |
| title_full_unstemmed | Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case Report |
| title_short | Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment – A Case Report |
| title_sort | intralesional spesolimab a novel and effective approach for palmoplantar pustulosis treatment ndash a case report |
| topic | palmoplantar pustulosis spesolimab intralesional injection case report |
| url | https://www.dovepress.com/intralesional-spesolimab-a-novel-and-effective-approach-for-palmoplant-peer-reviewed-fulltext-article-IMCRJ |
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