SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder punctuated by varied multiorgan complications all along the course of its natural history. Lymphoma represents a relatively well-recognized malignant phenomenon associated with lupus. The cause and effect relationships of lympho...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2017/1658473 |
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| author | Prajwal Boddu Abdul S. Mohammed Chandrahasa Annem Winston Sequeira |
| author_facet | Prajwal Boddu Abdul S. Mohammed Chandrahasa Annem Winston Sequeira |
| author_sort | Prajwal Boddu |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder punctuated by varied multiorgan complications all along the course of its natural history. Lymphoma represents a relatively well-recognized malignant phenomenon associated with lupus. The cause and effect relationships of lymphoma in SLE have been subject to extensive scrutiny with several studies reporting on clinic-pathologic characteristics and risk factors predicting lymphoma development in SLE. However, the pathogenic role of immunosuppressives in SLE-related lymphoma still remains unclear, and indices to help guide diagnosis, prognostication, therapy, and posttreatment monitoring are yet to be established. In this review, we describe 3 SLE patients who developed non-Hodgkin’s lymphoma at different time points of their disease. Through a careful dissection of the aforementioned cases, we intend to apprise readers of the currently available literature surrounding risk factors, management, and prognosis in SLE-related lymphoma. We will also review and discuss the implications of immunosuppressives in SLE-related lymphoma and the role of mycophenolate mofetil in SLE-related primary CNS lymphoma development. |
| format | Article |
| id | doaj-art-1c859c7baef446d6bf897705ea4cfe01 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-1c859c7baef446d6bf897705ea4cfe012025-02-03T00:59:23ZengWileyCase Reports in Rheumatology2090-68892090-68972017-01-01201710.1155/2017/16584731658473SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the LiteraturePrajwal Boddu0Abdul S. Mohammed1Chandrahasa Annem2Winston Sequeira3Department of Internal Medicine, Advocate Illinois Masonic Medical Center, 836 W. Wellington Avenue, Chicago, IL 60657, USADepartment of Internal Medicine, Advocate Illinois Masonic Medical Center, 836 W. Wellington Avenue, Chicago, IL 60657, USADepartment of Rheumatology, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USADepartment of Rheumatology, Rush University Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USASystemic lupus erythematosus (SLE) is a multisystem autoimmune disorder punctuated by varied multiorgan complications all along the course of its natural history. Lymphoma represents a relatively well-recognized malignant phenomenon associated with lupus. The cause and effect relationships of lymphoma in SLE have been subject to extensive scrutiny with several studies reporting on clinic-pathologic characteristics and risk factors predicting lymphoma development in SLE. However, the pathogenic role of immunosuppressives in SLE-related lymphoma still remains unclear, and indices to help guide diagnosis, prognostication, therapy, and posttreatment monitoring are yet to be established. In this review, we describe 3 SLE patients who developed non-Hodgkin’s lymphoma at different time points of their disease. Through a careful dissection of the aforementioned cases, we intend to apprise readers of the currently available literature surrounding risk factors, management, and prognosis in SLE-related lymphoma. We will also review and discuss the implications of immunosuppressives in SLE-related lymphoma and the role of mycophenolate mofetil in SLE-related primary CNS lymphoma development.http://dx.doi.org/10.1155/2017/1658473 |
| spellingShingle | Prajwal Boddu Abdul S. Mohammed Chandrahasa Annem Winston Sequeira SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature Case Reports in Rheumatology |
| title | SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature |
| title_full | SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature |
| title_fullStr | SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature |
| title_full_unstemmed | SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature |
| title_short | SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature |
| title_sort | sle and non hodgkin s lymphoma a case series and review of the literature |
| url | http://dx.doi.org/10.1155/2017/1658473 |
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