Targeting tumor-associated macrophage polarization with traditional Chinese medicine active ingredients: Dual reversal of chemoresistance and immunosuppression in tumor microenvironment

Targeting tumor-associated macrophage polarization with traditional Chinese medicine active ingredients: Dual reversal of chemoresistance and immunosuppression in tumor microenvironment

Chemotherapy resistance and immunosuppression are major causes of tumor treatment failure. The polarization state of tumor-associated macrophages (TAMs) is a central regulatory hub for both processes. Traditional Chinese medicine (TCM) has the characteristics of multi-component, multi-target, and mu...

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Bibliographic Details
Main Authors: Yafeng Qi, Jingnan Yan, Xixi Huang, Xiaodan Jiang, Rongrong Li, Jiayi Wan, Yangyang Li, Zhiming Miao, Zhongyang Song, Yongqi Liu, Liying Zhang, Zhiming Zhang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
Subjects:
Natural product
Tumor-associated macrophage (TAM)
Chemoresistance
Immunosuppression
Therapeutic potential
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002130
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