Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives
Mannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy. The resul...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/765768 |
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| author | P. C. Jagadish Neeraj Soni Amita Verma |
| author_facet | P. C. Jagadish Neeraj Soni Amita Verma |
| author_sort | P. C. Jagadish |
| collection | DOAJ |
| description | Mannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified
by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy. The result obtained confirms superiority of
microwave irradiation method over classical heating one. The molecular properties and Lipinski rule of five for compounds 3(a–e) were determined by Molinspiration.
The synthesized compounds were subsequently evaluated for the antioxidant activity. All the compounds were found in compliance with Lipinski “Rule of Five”,
and compound 3e having p-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin. |
| format | Article |
| id | doaj-art-1c81f8f9d93649da8f398aee65fce7a6 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-1c81f8f9d93649da8f398aee65fce7a62025-02-03T01:32:11ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/765768765768Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines DerivativesP. C. Jagadish0Neeraj Soni1Amita Verma2Manipal College of Pharmaceutical Sciences, Manipal, IndiaNovarstis Healthcare Private Limited, Hyderabad, Andhra Pradesh, IndiaDepartment of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences Deemed to be University, Allahabad, Uttar Pradesh 211007, IndiaMannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy. The result obtained confirms superiority of microwave irradiation method over classical heating one. The molecular properties and Lipinski rule of five for compounds 3(a–e) were determined by Molinspiration. The synthesized compounds were subsequently evaluated for the antioxidant activity. All the compounds were found in compliance with Lipinski “Rule of Five”, and compound 3e having p-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin.http://dx.doi.org/10.1155/2013/765768 |
| spellingShingle | P. C. Jagadish Neeraj Soni Amita Verma Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives Journal of Chemistry |
| title | Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives |
| title_full | Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives |
| title_fullStr | Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives |
| title_full_unstemmed | Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives |
| title_short | Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives |
| title_sort | design synthesis and in vitro antioxidant activity of 1 3 5 trisubstituted 2 pyrazolines derivatives |
| url | http://dx.doi.org/10.1155/2013/765768 |
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