pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors
Transient receptor potential classical or cation channels (TRPCs) are integral to tumor biology, particularly in maintaining Ca<sup>2+</sup> homeostasis within cancer cells. TRPC5, a pH-sensitive member of this family, may act as a signaling molecule in the altered microenvironment of so...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/14/7/823 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850077083689025536 |
|---|---|
| author | Lara Hopmann Judith Heider Dennis Niebel Katja Evert Florian Zeman Christoph M. Hammers Tobias Ettl Christoph Brochhausen Stephan Schreml |
| author_facet | Lara Hopmann Judith Heider Dennis Niebel Katja Evert Florian Zeman Christoph M. Hammers Tobias Ettl Christoph Brochhausen Stephan Schreml |
| author_sort | Lara Hopmann |
| collection | DOAJ |
| description | Transient receptor potential classical or cation channels (TRPCs) are integral to tumor biology, particularly in maintaining Ca<sup>2+</sup> homeostasis within cancer cells. TRPC5, a pH-sensitive member of this family, may act as a signaling molecule in the altered microenvironment of solid tumors, which are characterized by an inverted pH-gradient—with decreased extracellular and increased intracellular pH—that promotes tumor progression. This study addresses a gap in the field, as there is currently limited research on TRPC5, particularly regarding its potential role as a tumor marker. While TRPCs are known to be involved in cancer biology, the specific role of TRPC5 in solid tumors, including its potential role as a diagnostic marker, remains largely unexplored. This study is the first to examine TRPC5 expression profiles in common skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), and nevus cell nevi (NCN). Our findings reveal that the frequency of TRPC5 expression in BCC is significantly lower compared to SCC and epidermal portions of NCN and MM. These results suggest that TRPC5 could serve as an immunohistochemical marker to distinguish SCC from BCC. Additionally, this study lays the groundwork for future research into the role of TRPC5 in tumor progression and metastasis, especially since BCCs, which rarely metastasize, are predominantly negative for TRPC5. |
| format | Article |
| id | doaj-art-1c7ccb2810d14d06ae03b3cd05803550 |
| institution | DOAJ |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-1c7ccb2810d14d06ae03b3cd058035502025-08-20T02:45:53ZengMDPI AGBiology2079-77372025-07-0114782310.3390/biology14070823pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin TumorsLara Hopmann0Judith Heider1Dennis Niebel2Katja Evert3Florian Zeman4Christoph M. Hammers5Tobias Ettl6Christoph Brochhausen7Stephan Schreml8Department of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyDepartment of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyDepartment of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyInstitute of Pathology, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyCenter for Clinical Studies, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyDepartment of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyDepartment of Maxillofacial Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyInstitute of Pathology, Medical Faculty Mannheim, University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, GermanyDepartment of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, GermanyTransient receptor potential classical or cation channels (TRPCs) are integral to tumor biology, particularly in maintaining Ca<sup>2+</sup> homeostasis within cancer cells. TRPC5, a pH-sensitive member of this family, may act as a signaling molecule in the altered microenvironment of solid tumors, which are characterized by an inverted pH-gradient—with decreased extracellular and increased intracellular pH—that promotes tumor progression. This study addresses a gap in the field, as there is currently limited research on TRPC5, particularly regarding its potential role as a tumor marker. While TRPCs are known to be involved in cancer biology, the specific role of TRPC5 in solid tumors, including its potential role as a diagnostic marker, remains largely unexplored. This study is the first to examine TRPC5 expression profiles in common skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), and nevus cell nevi (NCN). Our findings reveal that the frequency of TRPC5 expression in BCC is significantly lower compared to SCC and epidermal portions of NCN and MM. These results suggest that TRPC5 could serve as an immunohistochemical marker to distinguish SCC from BCC. Additionally, this study lays the groundwork for future research into the role of TRPC5 in tumor progression and metastasis, especially since BCCs, which rarely metastasize, are predominantly negative for TRPC5.https://www.mdpi.com/2079-7737/14/7/823TRPC5skin tumorsmelanomasquamous cell carcinomabasal cell carcinoma |
| spellingShingle | Lara Hopmann Judith Heider Dennis Niebel Katja Evert Florian Zeman Christoph M. Hammers Tobias Ettl Christoph Brochhausen Stephan Schreml pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors Biology TRPC5 skin tumors melanoma squamous cell carcinoma basal cell carcinoma |
| title | pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors |
| title_full | pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors |
| title_fullStr | pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors |
| title_full_unstemmed | pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors |
| title_short | pH-Sensitive TRPC5 Is Differentially Expressed in Various Common Skin Tumors |
| title_sort | ph sensitive trpc5 is differentially expressed in various common skin tumors |
| topic | TRPC5 skin tumors melanoma squamous cell carcinoma basal cell carcinoma |
| url | https://www.mdpi.com/2079-7737/14/7/823 |
| work_keys_str_mv | AT larahopmann phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT judithheider phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT dennisniebel phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT katjaevert phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT florianzeman phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT christophmhammers phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT tobiasettl phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT christophbrochhausen phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors AT stephanschreml phsensitivetrpc5isdifferentiallyexpressedinvariouscommonskintumors |