Tuning gut microbiota by advanced nanotechnology

Gut microbiota reveals fundamental mechanisms of health and disease, and its modulation has important applications in biomedicine. Traditional modulation methods ( e.g. diet, antibiotics, and probiotics) suffer from drug resistance, poor targeting, and low efficiency. Nanotechnology has become an at...

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Main Authors: Yue Qi, Yueyi Wang, Xiaofei Wang, Hao Zheng, Yuan Lu
Format: Article
Language:English
Published: IOP Publishing 2025-01-01
Series:Materials Futures
Subjects:
Online Access:https://doi.org/10.1088/2752-5724/ada62b
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author Yue Qi
Yueyi Wang
Xiaofei Wang
Hao Zheng
Yuan Lu
author_facet Yue Qi
Yueyi Wang
Xiaofei Wang
Hao Zheng
Yuan Lu
author_sort Yue Qi
collection DOAJ
description Gut microbiota reveals fundamental mechanisms of health and disease, and its modulation has important applications in biomedicine. Traditional modulation methods ( e.g. diet, antibiotics, and probiotics) suffer from drug resistance, poor targeting, and low efficiency. Nanotechnology has become an attractive option for the precise modulation of gut microbiota due to its targeting and controllability. This review will focus on research progress in nanotechnology to modulate gut microbiota, including the direct use of nanomaterials as antimicrobials, nano-drug delivery systems, and stimulus-responsive nanotechnology. In addition, the applications of nanotechnology to modulate gut microbiota are summarized in terms of healthcare, animal protection, and agricultural development. Finally, the challenges and corresponding solution strategies for nanotechnology modulation are reviewed, and the future development prospects for nanotechnology modulation are summarized. This review provides an important theoretical basis and practical reference for the development of gut microbiota modulation, and promotes the research and application of more precise and efficient microbiota community intervention strategies.
format Article
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institution Kabale University
issn 2752-5724
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publishDate 2025-01-01
publisher IOP Publishing
record_format Article
series Materials Futures
spelling doaj-art-1c60413c9f954d00a23a5f4800167b0b2025-01-23T11:05:50ZengIOP PublishingMaterials Futures2752-57242025-01-014101230210.1088/2752-5724/ada62bTuning gut microbiota by advanced nanotechnologyYue Qi0Yueyi Wang1Xiaofei Wang2Hao Zheng3Yuan Lu4https://orcid.org/0000-0003-4500-6230College of Food Science and Nutritional Engineering, China Agricultural University , Beijing 100083, People’s Republic of China; Department of Chemical Engineering, Tsinghua University , Beijing 100084, People’s Republic of China; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University , Beijing 100084, People’s Republic of ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University , Beijing 100083, People’s Republic of China; Department of Chemical Engineering, Tsinghua University , Beijing 100084, People’s Republic of China; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University , Beijing 100084, People’s Republic of ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University , Beijing 100083, People’s Republic of ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University , Beijing 100083, People’s Republic of ChinaDepartment of Chemical Engineering, Tsinghua University , Beijing 100084, People’s Republic of China; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University , Beijing 100084, People’s Republic of ChinaGut microbiota reveals fundamental mechanisms of health and disease, and its modulation has important applications in biomedicine. Traditional modulation methods ( e.g. diet, antibiotics, and probiotics) suffer from drug resistance, poor targeting, and low efficiency. Nanotechnology has become an attractive option for the precise modulation of gut microbiota due to its targeting and controllability. This review will focus on research progress in nanotechnology to modulate gut microbiota, including the direct use of nanomaterials as antimicrobials, nano-drug delivery systems, and stimulus-responsive nanotechnology. In addition, the applications of nanotechnology to modulate gut microbiota are summarized in terms of healthcare, animal protection, and agricultural development. Finally, the challenges and corresponding solution strategies for nanotechnology modulation are reviewed, and the future development prospects for nanotechnology modulation are summarized. This review provides an important theoretical basis and practical reference for the development of gut microbiota modulation, and promotes the research and application of more precise and efficient microbiota community intervention strategies.https://doi.org/10.1088/2752-5724/ada62bnanotechnologygut microbiotamodulationdrug delivery
spellingShingle Yue Qi
Yueyi Wang
Xiaofei Wang
Hao Zheng
Yuan Lu
Tuning gut microbiota by advanced nanotechnology
Materials Futures
nanotechnology
gut microbiota
modulation
drug delivery
title Tuning gut microbiota by advanced nanotechnology
title_full Tuning gut microbiota by advanced nanotechnology
title_fullStr Tuning gut microbiota by advanced nanotechnology
title_full_unstemmed Tuning gut microbiota by advanced nanotechnology
title_short Tuning gut microbiota by advanced nanotechnology
title_sort tuning gut microbiota by advanced nanotechnology
topic nanotechnology
gut microbiota
modulation
drug delivery
url https://doi.org/10.1088/2752-5724/ada62b
work_keys_str_mv AT yueqi tuninggutmicrobiotabyadvancednanotechnology
AT yueyiwang tuninggutmicrobiotabyadvancednanotechnology
AT xiaofeiwang tuninggutmicrobiotabyadvancednanotechnology
AT haozheng tuninggutmicrobiotabyadvancednanotechnology
AT yuanlu tuninggutmicrobiotabyadvancednanotechnology