ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer
Aim. To explore the correlations between the expression of zinc finger protein 521 (ZNF521) with immune invasion and prognosis of gastric cancer. Methods. Expression of ZNF521 was examined by immunohistochemistry in gastric cancer cases. Kaplan–Meier plotter was used to determine the relationships b...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/5288075 |
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| author | Li Li Zheng-Hui Liu Hui-Ju Wang Lei Wang Guo-Qing Ru Yuan-Yu Wang |
| author_facet | Li Li Zheng-Hui Liu Hui-Ju Wang Lei Wang Guo-Qing Ru Yuan-Yu Wang |
| author_sort | Li Li |
| collection | DOAJ |
| description | Aim. To explore the correlations between the expression of zinc finger protein 521 (ZNF521) with immune invasion and prognosis of gastric cancer. Methods. Expression of ZNF521 was examined by immunohistochemistry in gastric cancer cases. Kaplan–Meier plotter was used to determine the relationships between ZNF521 and prognosis. TIMER and GEPIA were used to analyze the correlation between ZNF521 expression and gene markers of immune cell infiltration. Results. The expression of ZNF521 was up-regulated in gastric cancer samples. Kaplan–Meier analysis indicated that higher expression of ZNF521 was associated with poor prognosis. The expression of ZNF521 was correlated with infiltrating levels of CD4+ T and CD8+ T cells, macrophages, neutrophils, and dendritic cells in gastric cancer, which also correlated with diverse immune marker sets. Conclusions. ZNF521 is correlated significantly with immune cell infiltration and is a valuable biomarker for prognosis in gastric cancer. |
| format | Article |
| id | doaj-art-1c58b6b522e14b1e9a7a5207b2d77933 |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-1c58b6b522e14b1e9a7a5207b2d779332025-02-03T01:07:55ZengWileyGastroenterology Research and Practice1687-630X2022-01-01202210.1155/2022/5288075ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric CancerLi Li0Zheng-Hui Liu1Hui-Ju Wang2Lei Wang3Guo-Qing Ru4Yuan-Yu Wang5General SurgeryGraduate School of Bengbu Medical UniversityGeneral SurgeryDepartment of Gastrointestinal SurgeryCancer CenterGeneral SurgeryAim. To explore the correlations between the expression of zinc finger protein 521 (ZNF521) with immune invasion and prognosis of gastric cancer. Methods. Expression of ZNF521 was examined by immunohistochemistry in gastric cancer cases. Kaplan–Meier plotter was used to determine the relationships between ZNF521 and prognosis. TIMER and GEPIA were used to analyze the correlation between ZNF521 expression and gene markers of immune cell infiltration. Results. The expression of ZNF521 was up-regulated in gastric cancer samples. Kaplan–Meier analysis indicated that higher expression of ZNF521 was associated with poor prognosis. The expression of ZNF521 was correlated with infiltrating levels of CD4+ T and CD8+ T cells, macrophages, neutrophils, and dendritic cells in gastric cancer, which also correlated with diverse immune marker sets. Conclusions. ZNF521 is correlated significantly with immune cell infiltration and is a valuable biomarker for prognosis in gastric cancer.http://dx.doi.org/10.1155/2022/5288075 |
| spellingShingle | Li Li Zheng-Hui Liu Hui-Ju Wang Lei Wang Guo-Qing Ru Yuan-Yu Wang ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer Gastroenterology Research and Practice |
| title | ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer |
| title_full | ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer |
| title_fullStr | ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer |
| title_full_unstemmed | ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer |
| title_short | ZNF521 Is Correlated with Tumor Immune Cell Infiltration and Act as a Valuable Prognostic Biomarker in Gastric Cancer |
| title_sort | znf521 is correlated with tumor immune cell infiltration and act as a valuable prognostic biomarker in gastric cancer |
| url | http://dx.doi.org/10.1155/2022/5288075 |
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