Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease
Acute sickle hepatic crisis (ASHC) has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS) sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2015/761740 |
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| author | J. H. Gillis S. K. Satapathy L. Parsa P. B. Sylvestre N. Dbouk |
| author_facet | J. H. Gillis S. K. Satapathy L. Parsa P. B. Sylvestre N. Dbouk |
| author_sort | J. H. Gillis |
| collection | DOAJ |
| description | Acute sickle hepatic crisis (ASHC) has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS) sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepatomegaly, and mild to moderate elevations in serum AST, ALT, and bilirubin. We describe the case of a patient with a history of hemoglobin SC disease and cirrhosis caused by hepatitis C presenting approximately 1 year after liver transplantation with an ASHC. The diagnosis was confirmed by liver biopsy. Our patient was treated with RBC exchange transfusions, IV hydration, and analgesia and made a complete recovery. Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease. |
| format | Article |
| id | doaj-art-1c56697710114254ac9d8d9a1b4db14e |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-1c56697710114254ac9d8d9a1b4db14e2025-02-03T06:13:21ZengWileyCase Reports in Transplantation2090-69432090-69512015-01-01201510.1155/2015/761740761740Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC DiseaseJ. H. Gillis0S. K. Satapathy1L. Parsa2P. B. Sylvestre3N. Dbouk4Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN 38104, USADepartment of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38104, USADepartment of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN 38104, USADepartment of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38104, USADepartment of Surgery, The University of Tennessee Health Science Center, Memphis, TN 38104, USAAcute sickle hepatic crisis (ASHC) has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS) sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepatomegaly, and mild to moderate elevations in serum AST, ALT, and bilirubin. We describe the case of a patient with a history of hemoglobin SC disease and cirrhosis caused by hepatitis C presenting approximately 1 year after liver transplantation with an ASHC. The diagnosis was confirmed by liver biopsy. Our patient was treated with RBC exchange transfusions, IV hydration, and analgesia and made a complete recovery. Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease.http://dx.doi.org/10.1155/2015/761740 |
| spellingShingle | J. H. Gillis S. K. Satapathy L. Parsa P. B. Sylvestre N. Dbouk Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease Case Reports in Transplantation |
| title | Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease |
| title_full | Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease |
| title_fullStr | Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease |
| title_full_unstemmed | Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease |
| title_short | Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease |
| title_sort | acute sickle hepatic crisis after liver transplantation in a patient with hb sc disease |
| url | http://dx.doi.org/10.1155/2015/761740 |
| work_keys_str_mv | AT jhgillis acutesicklehepaticcrisisafterlivertransplantationinapatientwithhbscdisease AT sksatapathy acutesicklehepaticcrisisafterlivertransplantationinapatientwithhbscdisease AT lparsa acutesicklehepaticcrisisafterlivertransplantationinapatientwithhbscdisease AT pbsylvestre acutesicklehepaticcrisisafterlivertransplantationinapatientwithhbscdisease AT ndbouk acutesicklehepaticcrisisafterlivertransplantationinapatientwithhbscdisease |