Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic h...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/4038397 |
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| author | Krishna Adit Agarwal Myat Han Soe |
| author_facet | Krishna Adit Agarwal Myat Han Soe |
| author_sort | Krishna Adit Agarwal |
| collection | DOAJ |
| description | We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC. In addition, we discuss neuroendocrine differentiation and ectopic hormone production in relation to intratumoral heterogeneity in SCLC and propose tumor microenvironment and hormonal and metabolic dependence as important determinants of tumor growth and survival. |
| format | Article |
| id | doaj-art-1c53b7dea9a1458bbbf9db9d1189a036 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-1c53b7dea9a1458bbbf9db9d1189a0362025-02-03T05:57:48ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/40383974038397Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future ImplicationsKrishna Adit Agarwal0Myat Han Soe1Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, USADepartment of Medicine, Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, USAWe present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC. In addition, we discuss neuroendocrine differentiation and ectopic hormone production in relation to intratumoral heterogeneity in SCLC and propose tumor microenvironment and hormonal and metabolic dependence as important determinants of tumor growth and survival.http://dx.doi.org/10.1155/2018/4038397 |
| spellingShingle | Krishna Adit Agarwal Myat Han Soe Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications Case Reports in Oncological Medicine |
| title | Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications |
| title_full | Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications |
| title_fullStr | Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications |
| title_full_unstemmed | Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications |
| title_short | Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications |
| title_sort | beyond the dual paraneoplastic syndromes of small cell lung cancer with adh and acth secretion a case report with literature review and future implications |
| url | http://dx.doi.org/10.1155/2018/4038397 |
| work_keys_str_mv | AT krishnaaditagarwal beyondthedualparaneoplasticsyndromesofsmallcelllungcancerwithadhandacthsecretionacasereportwithliteraturereviewandfutureimplications AT myathansoe beyondthedualparaneoplasticsyndromesofsmallcelllungcancerwithadhandacthsecretionacasereportwithliteraturereviewandfutureimplications |