Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects
This paper presents a comprehensive review of the current literature, clinical trials, and products approved for the delivery of antibiotics to the lungs. While there are many literature reports describing potential delivery systems, few of these have translated into marketed products. Key challenge...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/1/111 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587693251362816 |
|---|---|
| author | Yahya H. Dallal Bashi Rachel Mairs Rand Murtadha Vicky Kett |
| author_facet | Yahya H. Dallal Bashi Rachel Mairs Rand Murtadha Vicky Kett |
| author_sort | Yahya H. Dallal Bashi |
| collection | DOAJ |
| description | This paper presents a comprehensive review of the current literature, clinical trials, and products approved for the delivery of antibiotics to the lungs. While there are many literature reports describing potential delivery systems, few of these have translated into marketed products. Key challenges remaining are the high doses required and, for powder formulations, the ability of the inhaler and powder combination to deliver the dose to the correct portion of the respiratory tract for maximum effect. Side effects, safety concerns, and disappointing clinical trial results remain barriers to regulatory approval. In this review, we describe some possible approaches to address these issues and highlight prospects in this area. |
| format | Article |
| id | doaj-art-1c52a3b6287b480c9dc5c58e44cd8e4f |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-1c52a3b6287b480c9dc5c58e44cd8e4f2025-01-24T13:46:00ZengMDPI AGPharmaceutics1999-49232025-01-0117111110.3390/pharmaceutics17010111Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future ProspectsYahya H. Dallal Bashi0Rachel Mairs1Rand Murtadha2Vicky Kett3School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UKSchool of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UKSchool of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UKSchool of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UKThis paper presents a comprehensive review of the current literature, clinical trials, and products approved for the delivery of antibiotics to the lungs. While there are many literature reports describing potential delivery systems, few of these have translated into marketed products. Key challenges remaining are the high doses required and, for powder formulations, the ability of the inhaler and powder combination to deliver the dose to the correct portion of the respiratory tract for maximum effect. Side effects, safety concerns, and disappointing clinical trial results remain barriers to regulatory approval. In this review, we describe some possible approaches to address these issues and highlight prospects in this area.https://www.mdpi.com/1999-4923/17/1/111cystic fibrosisbronchiectasisinhalationDPInebulizertobramycin |
| spellingShingle | Yahya H. Dallal Bashi Rachel Mairs Rand Murtadha Vicky Kett Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects Pharmaceutics cystic fibrosis bronchiectasis inhalation DPI nebulizer tobramycin |
| title | Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects |
| title_full | Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects |
| title_fullStr | Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects |
| title_full_unstemmed | Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects |
| title_short | Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects |
| title_sort | pulmonary delivery of antibiotics to the lungs current state and future prospects |
| topic | cystic fibrosis bronchiectasis inhalation DPI nebulizer tobramycin |
| url | https://www.mdpi.com/1999-4923/17/1/111 |
| work_keys_str_mv | AT yahyahdallalbashi pulmonarydeliveryofantibioticstothelungscurrentstateandfutureprospects AT rachelmairs pulmonarydeliveryofantibioticstothelungscurrentstateandfutureprospects AT randmurtadha pulmonarydeliveryofantibioticstothelungscurrentstateandfutureprospects AT vickykett pulmonarydeliveryofantibioticstothelungscurrentstateandfutureprospects |