Dam and its role in pathogenicity of Salmonella enterica
Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2009-08-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/465 |
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| author | Mónica N. Giacomodonato Sebastián H. Sarnacki Mariángeles Noto Llana M. Cristina Cerquetti |
| author_facet | Mónica N. Giacomodonato Sebastián H. Sarnacki Mariángeles Noto Llana M. Cristina Cerquetti |
| author_sort | Mónica N. Giacomodonato |
| collection | DOAJ |
| description | Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica. |
| format | Article |
| id | doaj-art-1c4ab6546fd04e52b51a5cabb38a4071 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2009-08-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-1c4ab6546fd04e52b51a5cabb38a40712025-08-20T02:16:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-08-0130710.3855/jidc.465Dam and its role in pathogenicity of Salmonella entericaMónica N. Giacomodonato0Sebastián H. Sarnacki1Mariángeles Noto Llana2M. Cristina Cerquetti3Centro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos AiresCentro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos AiresCentro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos AiresCentro de Estudios Farmacológicos y Botánicos CEFyBO-CONICET, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos AiresDam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.https://jidc.org/index.php/journal/article/view/465DNA adenine methylasePathogenesisSalmonella enterica |
| spellingShingle | Mónica N. Giacomodonato Sebastián H. Sarnacki Mariángeles Noto Llana M. Cristina Cerquetti Dam and its role in pathogenicity of Salmonella enterica Journal of Infection in Developing Countries DNA adenine methylase Pathogenesis Salmonella enterica |
| title | Dam and its role in pathogenicity of Salmonella enterica |
| title_full | Dam and its role in pathogenicity of Salmonella enterica |
| title_fullStr | Dam and its role in pathogenicity of Salmonella enterica |
| title_full_unstemmed | Dam and its role in pathogenicity of Salmonella enterica |
| title_short | Dam and its role in pathogenicity of Salmonella enterica |
| title_sort | dam and its role in pathogenicity of salmonella enterica |
| topic | DNA adenine methylase Pathogenesis Salmonella enterica |
| url | https://jidc.org/index.php/journal/article/view/465 |
| work_keys_str_mv | AT monicangiacomodonato damanditsroleinpathogenicityofsalmonellaenterica AT sebastianhsarnacki damanditsroleinpathogenicityofsalmonellaenterica AT mariangelesnotollana damanditsroleinpathogenicityofsalmonellaenterica AT mcristinacerquetti damanditsroleinpathogenicityofsalmonellaenterica |