A mathematical model of stem cell regeneration with epigenetic state transitions
In this paper, we study a mathematical model of stem cell regeneration with epigenetic state transitions. In the model, the heterogeneity of stem cells is considered through the epigenetic state of each cell, and each epigenetic state defines a subpopulation of stem cells. The dynamics of the subpop...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2017-09-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2017071 |
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| Summary: | In this paper, we study a mathematical model of stem cell regeneration with epigenetic state transitions. In the model, the heterogeneity of stem cells is considered through the epigenetic state of each cell, and each epigenetic state defines a subpopulation of stem cells. The dynamics of the subpopulations are modeled by a set of ordinary differential equations in which epigenetic state transition in cell division is given by the transition probability. We present analysis for the existence and linear stability of the equilibrium state. As an example, we apply the model to study the dynamics of state transition in breast cancer stem cells. |
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| ISSN: | 1551-0018 |