Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers
We investigated whether metalloproteinase-9 (MMP-9) values in induced sputum (IS) and pulmonary function tests can serve as a marker of damage and intensity of exposure to hazardous dust. Thirty-nine factory employees (28 workers exposed to metal particles and 11 supposedly nonexposed office workers...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/24827 |
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| _version_ | 1832552065495203840 |
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| author | Yehuda Lerman Abraham Moscovich Elizabeth Fireman |
| author_facet | Yehuda Lerman Abraham Moscovich Elizabeth Fireman |
| author_sort | Yehuda Lerman |
| collection | DOAJ |
| description | We investigated whether metalloproteinase-9 (MMP-9) values in
induced sputum (IS) and pulmonary function tests can serve
as a marker of damage and intensity of exposure to hazardous dust.
Thirty-nine factory employees (28 workers exposed to metal
particles and 11 supposedly nonexposed office workers) underwent
IS induction. Samples were processed by conventional methods
within 2 hours. The proportion of particles with diameters of
0–2 μ in IS samples was significantly higher in
nonexposed than exposed workers and in smoker compared to nonsmoker workers. MMP-9 and
TIMP-1 levels were similar for both groups. A linear regression
model for MMP-9 based on exposure, smoking habits, and proportion
of particles <5 μ revealed a positive correlation
between each of the explanatory variables and MMP-9 values. MMP-9
may serve as a marker for pulmonary injury. |
| format | Article |
| id | doaj-art-1c4044d8423d400d8e4479fabb9f80dd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1c4044d8423d400d8e4479fabb9f80dd2025-02-03T05:59:34ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/2482724827Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed WorkersYehuda Lerman0Abraham Moscovich1Elizabeth Fireman2Occupational and Environmental Health Center, Clalit Health Services, Tel-Aviv, IsraelOccupational and Environmental Health Center, Clalit Health Services, Tel-Aviv, IsraelThe Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, IsraelWe investigated whether metalloproteinase-9 (MMP-9) values in induced sputum (IS) and pulmonary function tests can serve as a marker of damage and intensity of exposure to hazardous dust. Thirty-nine factory employees (28 workers exposed to metal particles and 11 supposedly nonexposed office workers) underwent IS induction. Samples were processed by conventional methods within 2 hours. The proportion of particles with diameters of 0–2 μ in IS samples was significantly higher in nonexposed than exposed workers and in smoker compared to nonsmoker workers. MMP-9 and TIMP-1 levels were similar for both groups. A linear regression model for MMP-9 based on exposure, smoking habits, and proportion of particles <5 μ revealed a positive correlation between each of the explanatory variables and MMP-9 values. MMP-9 may serve as a marker for pulmonary injury.http://dx.doi.org/10.1155/MI/2006/24827 |
| spellingShingle | Yehuda Lerman Abraham Moscovich Elizabeth Fireman Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers Mediators of Inflammation |
| title | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_full | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_fullStr | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_full_unstemmed | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_short | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_sort | unexpected smoking linked high mmp 9 in induced sputum of hazardous dust exposed workers |
| url | http://dx.doi.org/10.1155/MI/2006/24827 |
| work_keys_str_mv | AT yehudalerman unexpectedsmokinglinkedhighmmp9ininducedsputumofhazardousdustexposedworkers AT abrahammoscovich unexpectedsmokinglinkedhighmmp9ininducedsputumofhazardousdustexposedworkers AT elizabethfireman unexpectedsmokinglinkedhighmmp9ininducedsputumofhazardousdustexposedworkers |