Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers
We investigated whether metalloproteinase-9 (MMP-9) values in induced sputum (IS) and pulmonary function tests can serve as a marker of damage and intensity of exposure to hazardous dust. Thirty-nine factory employees (28 workers exposed to metal particles and 11 supposedly nonexposed office workers...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/24827 |
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| Summary: | We investigated whether metalloproteinase-9 (MMP-9) values in
induced sputum (IS) and pulmonary function tests can serve
as a marker of damage and intensity of exposure to hazardous dust.
Thirty-nine factory employees (28 workers exposed to metal
particles and 11 supposedly nonexposed office workers) underwent
IS induction. Samples were processed by conventional methods
within 2 hours. The proportion of particles with diameters of
0–2 μ in IS samples was significantly higher in
nonexposed than exposed workers and in smoker compared to nonsmoker workers. MMP-9 and
TIMP-1 levels were similar for both groups. A linear regression
model for MMP-9 based on exposure, smoking habits, and proportion
of particles <5 μ revealed a positive correlation
between each of the explanatory variables and MMP-9 values. MMP-9
may serve as a marker for pulmonary injury. |
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| ISSN: | 0962-9351 1466-1861 |