Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation
Objective: To investigate the relationship between vitamin D deficiency and mastalgia and assess the effectiveness of vitamin D supplementation in alleviating mastalgia symptoms. Materials and Methods: A prospective investigational study conducted in an Indian tertiary teaching centre. Participants...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-04-01
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| Series: | European Journal of Breast Health |
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| Online Access: | https://www.eurjbreasthealth.com/articles/vitamin-d-deficiency-and-mastalgia-a-prospective-controlled-study-on-prevalence-and-the-therapeutic-impact-of-supplementation/doi/ejbh.galenos.2025.2025-1-6 |
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| author | Goranta Navya Sree Sanjay Kumar Yadav Deepti Bala Sharma Dhananjaya Sharma Saket Shekhar |
| author_facet | Goranta Navya Sree Sanjay Kumar Yadav Deepti Bala Sharma Dhananjaya Sharma Saket Shekhar |
| author_sort | Goranta Navya Sree |
| collection | DOAJ |
| description | Objective: To investigate the relationship between vitamin D deficiency and mastalgia and assess the effectiveness of vitamin D supplementation in alleviating mastalgia symptoms.
Materials and Methods: A prospective investigational study conducted in an Indian tertiary teaching centre. Participants were included if the presented with mastalgia and controls without mastalgia were also were recruited. Exclusion criteria were malignant pathology; fibroadenoma; other benign breast diseases; or recent therapeutic vitamin D supplementation. Vitamin D deficiency was classified as <20 ng/mL. Women in the mastalgia group with deficiency received 60,000 IU weekly oral vitamin D for eight weeks. Symptom severity was evaluated using a visual analog scale (VAS) at baseline and follow-up intervals of 4, 8, and 12 weeks. Difference in serum vitamin D levels between groups and changes in VAS scores post-supplementation was assessed.
Results: A total of 200 women, including 100 with mastalgia and 100 without (control group), were recruited over two years.The mean serum vitamin D level was significantly lower in the mastalgia group (25.29±7.7 ng/mL) compared to controls (31.46±8.5 ng/mL, p<0.0001). Vitamin D deficiency was more prevalent in the mastalgia group (26% vs. 9%, p = 0.001). Post-supplementation, 46% of deficient patients in the mastalgia group reported symptom improvement, with 21% achieving complete resolution. However, 54% reported persistent symptoms despite achieving sufficient vitamin D levels.
Conclusion: Vitamin D deficiency is more prevalent in Indian women with mastalgia, and supplementation provides symptomatic relief for some patients. However, a significant proportion of patients continue to experience symptoms, suggesting other underlying factors contributing to mastalgia. Further research is needed to explore these factors and optimize management strategies. |
| format | Article |
| id | doaj-art-1c3a10d50b2e4128b7d69fba5bcd6ea2 |
| institution | OA Journals |
| issn | 2587-0831 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj-art-1c3a10d50b2e4128b7d69fba5bcd6ea22025-08-20T01:49:47ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312025-04-0121213714010.4274/ejbh.galenos.2025.2025-1-6Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of SupplementationGoranta Navya Sree0https://orcid.org/0009-0006-1642-2779Sanjay Kumar Yadav1https://orcid.org/0000-0002-0682-4970Deepti Bala Sharma2https://orcid.org/0000-0003-0951-8482Dhananjaya Sharma3https://orcid.org/0000-0002-0604-8676Saket Shekhar4https://orcid.org/0000-0002-6021-2465Department of Surgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, IndiaDivision of Breast and Endocrine Surgery, Department of Surgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, IndiaDepartment of Surgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, IndiaDepartment of Surgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, IndiaDepartment of Biostatistics and PSM, ESIC Medical College, Patna, IndiaObjective: To investigate the relationship between vitamin D deficiency and mastalgia and assess the effectiveness of vitamin D supplementation in alleviating mastalgia symptoms. Materials and Methods: A prospective investigational study conducted in an Indian tertiary teaching centre. Participants were included if the presented with mastalgia and controls without mastalgia were also were recruited. Exclusion criteria were malignant pathology; fibroadenoma; other benign breast diseases; or recent therapeutic vitamin D supplementation. Vitamin D deficiency was classified as <20 ng/mL. Women in the mastalgia group with deficiency received 60,000 IU weekly oral vitamin D for eight weeks. Symptom severity was evaluated using a visual analog scale (VAS) at baseline and follow-up intervals of 4, 8, and 12 weeks. Difference in serum vitamin D levels between groups and changes in VAS scores post-supplementation was assessed. Results: A total of 200 women, including 100 with mastalgia and 100 without (control group), were recruited over two years.The mean serum vitamin D level was significantly lower in the mastalgia group (25.29±7.7 ng/mL) compared to controls (31.46±8.5 ng/mL, p<0.0001). Vitamin D deficiency was more prevalent in the mastalgia group (26% vs. 9%, p = 0.001). Post-supplementation, 46% of deficient patients in the mastalgia group reported symptom improvement, with 21% achieving complete resolution. However, 54% reported persistent symptoms despite achieving sufficient vitamin D levels. Conclusion: Vitamin D deficiency is more prevalent in Indian women with mastalgia, and supplementation provides symptomatic relief for some patients. However, a significant proportion of patients continue to experience symptoms, suggesting other underlying factors contributing to mastalgia. Further research is needed to explore these factors and optimize management strategies.https://www.eurjbreasthealth.com/articles/vitamin-d-deficiency-and-mastalgia-a-prospective-controlled-study-on-prevalence-and-the-therapeutic-impact-of-supplementation/doi/ejbh.galenos.2025.2025-1-6mastalgiavitamin d deficiencyserum vitamin d levelsvitamin d supplementationprospective studyrandomized controlled studysymptom reliefvisual analog scale |
| spellingShingle | Goranta Navya Sree Sanjay Kumar Yadav Deepti Bala Sharma Dhananjaya Sharma Saket Shekhar Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation European Journal of Breast Health mastalgia vitamin d deficiency serum vitamin d levels vitamin d supplementation prospective study randomized controlled study symptom relief visual analog scale |
| title | Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation |
| title_full | Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation |
| title_fullStr | Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation |
| title_full_unstemmed | Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation |
| title_short | Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation |
| title_sort | vitamin d deficiency and mastalgia a prospective controlled study on prevalence and the therapeutic impact of supplementation |
| topic | mastalgia vitamin d deficiency serum vitamin d levels vitamin d supplementation prospective study randomized controlled study symptom relief visual analog scale |
| url | https://www.eurjbreasthealth.com/articles/vitamin-d-deficiency-and-mastalgia-a-prospective-controlled-study-on-prevalence-and-the-therapeutic-impact-of-supplementation/doi/ejbh.galenos.2025.2025-1-6 |
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