Tumor-derived extracellular vesicles disrupt the blood–brain barrier endothelium following high-frequency irreversible electroporation

Tumor-derived extracellular vesicles disrupt the blood–brain barrier endothelium following high-frequency irreversible electroporation

Abstract High-frequency irreversible electroporation (H-FIRE), a nonthermal brain tumor ablation therapeutic, generates a central tumor ablation zone while transiently disrupting the peritumoral blood–brain barrier (BBB). We hypothesized that bystander effects of H-FIRE tumor cell ablation, mediated...

Full description

Saved in:
Bibliographic Details
Main Authors: Kelsey R. Murphy, Kenneth N. Aycock, Spencer Marsh, Alayna N. Hay, Ilektra Athanasiadi, Shay Bracha, Christine Chang, Robert Gourdie, Rafael V. Davalos, John H. Rossmeisl, Nikolaos G. Dervisis
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-79019-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-024-79019-5

Similar Items