NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex development

NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex development

Abstract Testicular fetal Leydig cells produce androgens essential for male reproductive development. Impaired fetal Leydig cell differentiation leads to differences of sex development including hypospadias, cryptorchidism, and infertility. Despite fetal Leydig cells are thought to originate from pr...

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Bibliographic Details
Main Authors: Martín Andrés Estermann, Sara A. Grimm, Abigail S. Kitakule, Karina F. Rodriguez, Paula R. Brown, Kathryn McClelland, Ciro M. Amato, Humphrey Hung-Chang Yao
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59183-6
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