Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan
Objective: Multisystem inflammatory syndrome of childhood (MIS-C) is a newly recognized entity associated with COVID-19 in children. The objective was to describe the clinical course for 74 patients diagnosed with this disease. Methods: A multicenter retrospective study including 5 major hospitals i...
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Elsevier
2025-06-01
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| Series: | Global Epidemiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590113325000033 |
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| author | Marwan Shalabi Salam Ghanem Iyad Al-Ammouri Amirah Daher Enas Al-zayadneh Alaa Alsmadi Mais Ayyoub Samah Abughanam Mariam Jabr Montaha Al-Iede |
| author_facet | Marwan Shalabi Salam Ghanem Iyad Al-Ammouri Amirah Daher Enas Al-zayadneh Alaa Alsmadi Mais Ayyoub Samah Abughanam Mariam Jabr Montaha Al-Iede |
| author_sort | Marwan Shalabi |
| collection | DOAJ |
| description | Objective: Multisystem inflammatory syndrome of childhood (MIS-C) is a newly recognized entity associated with COVID-19 in children. The objective was to describe the clinical course for 74 patients diagnosed with this disease. Methods: A multicenter retrospective study including 5 major hospitals in Jordan was conducted. Data from children admitted with confirmed SARS-CoV-2 infection or were in close contact with confirmed cases were collected. Total of 74 patients were diagnosed with MIS-C. Clinical, laboratory, radiological and therapeutic data were collected by retrospective chart review. Results: Fever, abdominal pain, hypoxia and other manifestation occurred. Cardiac findings were less common and did not include coronary findings. Treatments were mainly Corticosteroids and IVIG. No mortality was found in this series but serious disease occurred and some patients were admitted to Pediatric Intensive Care Unit. Conclusions: This study described the epidemiology, clinical course, management, and outcome of MIS-C cases in Jordan. The findings were consistent with what has been described from other regions globally. There was a wide spectrum in the severity of presentation. Abdominal pain was more prevalent and some children were misdiagnosed as surgical acute abdomen. |
| format | Article |
| id | doaj-art-1c2df41864c5455698e30ea6cba0c368 |
| institution | Kabale University |
| issn | 2590-1133 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Global Epidemiology |
| spelling | doaj-art-1c2df41864c5455698e30ea6cba0c3682025-01-27T04:22:09ZengElsevierGlobal Epidemiology2590-11332025-06-019100185Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from JordanMarwan Shalabi0Salam Ghanem1Iyad Al-Ammouri2Amirah Daher3Enas Al-zayadneh4Alaa Alsmadi5Mais Ayyoub6Samah Abughanam7Mariam Jabr8Montaha Al-Iede9Department of Pediatrics, School of Medicine, The Hashemite University, Amman, JordanDepartment of Health, Jordan Field Office, United Nations Relief and Works Agency for Palestine Refugees in the Near East, (UNRWA), Amman, JordanDepartment of Pediatrics, School of Medicine, The University of Jordan, Amman, JordanDepartment of Pediatrics, School of Medicine, The University of Jordan, Amman, JordanDepartment of Pediatrics, School of Medicine, The University of Jordan, Amman, JordanDepartment of Pediatrics and Neonatology, Islamic Hospital, Specialty Hospital, Jordan Hospital, Amman, JordanDepartment of Pediatrics and Neonatology, Islamic Hospital, Specialty Hospital, Jordan Hospital, Amman, JordanDepartment of Pediatrics and Neonatology, Islamic Hospital, Specialty Hospital, Jordan Hospital, Amman, JordanDepartment of Pediatrics and Neonatology, Islamic Hospital, Specialty Hospital, Jordan Hospital, Amman, JordanDepartment of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan; Corresponding author at: Department of Pediatrics, School of Medicine, The University of Jordan, Queen Rania Street, Amman 11942, Jordan.Objective: Multisystem inflammatory syndrome of childhood (MIS-C) is a newly recognized entity associated with COVID-19 in children. The objective was to describe the clinical course for 74 patients diagnosed with this disease. Methods: A multicenter retrospective study including 5 major hospitals in Jordan was conducted. Data from children admitted with confirmed SARS-CoV-2 infection or were in close contact with confirmed cases were collected. Total of 74 patients were diagnosed with MIS-C. Clinical, laboratory, radiological and therapeutic data were collected by retrospective chart review. Results: Fever, abdominal pain, hypoxia and other manifestation occurred. Cardiac findings were less common and did not include coronary findings. Treatments were mainly Corticosteroids and IVIG. No mortality was found in this series but serious disease occurred and some patients were admitted to Pediatric Intensive Care Unit. Conclusions: This study described the epidemiology, clinical course, management, and outcome of MIS-C cases in Jordan. The findings were consistent with what has been described from other regions globally. There was a wide spectrum in the severity of presentation. Abdominal pain was more prevalent and some children were misdiagnosed as surgical acute abdomen.http://www.sciencedirect.com/science/article/pii/S2590113325000033PediatricCOVID-19Critical careMultisystem inflammatory syndrome temporally associated with COVID-19SARS-CoV-2Shock |
| spellingShingle | Marwan Shalabi Salam Ghanem Iyad Al-Ammouri Amirah Daher Enas Al-zayadneh Alaa Alsmadi Mais Ayyoub Samah Abughanam Mariam Jabr Montaha Al-Iede Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan Global Epidemiology Pediatric COVID-19 Critical care Multisystem inflammatory syndrome temporally associated with COVID-19 SARS-CoV-2 Shock |
| title | Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan |
| title_full | Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan |
| title_fullStr | Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan |
| title_full_unstemmed | Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan |
| title_short | Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan |
| title_sort | multisystem inflammatory syndrome in children mis c associated with covid 19 clinical characteristics a multi center observational study from jordan |
| topic | Pediatric COVID-19 Critical care Multisystem inflammatory syndrome temporally associated with COVID-19 SARS-CoV-2 Shock |
| url | http://www.sciencedirect.com/science/article/pii/S2590113325000033 |
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