Immune-checkpoint targeting drug conjugates: a novel class of promising therapeutic agents for cancer treatment

Abstract Immune-checkpoint targeting Drug Conjugates (IDCs) are a novel class of therapeutics that combine an immune checkpoint-targeting moiety, a cleavable linker, and a cytotoxic payload. By integrating features and functions of antibody-drug conjugates and immunotherapy, IDCs represent a promisi...

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Bibliographic Details
Main Authors: Silvia Marchesi, Arianna Marinello, Paolo Ambrosini, Chiara Cavalli, Giuseppe Lo Russo, Mario Occhipinti
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01011-7
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