CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER
Aims of study: evaluation of immunological parameters in course of sublingual allergen-specific immunotherapy with tree pollen mixture in children with hay fever.Materials and methods: the study included one-hundred patients 5 to 18 years of age with hay fever (pollen rhinitis, rhinoconjunctivitis a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849241462220259328 |
|---|---|
| author | I. M. Gaiduk D. S. Korostovtsev N. L. Shaporova D. V. Breykin O. V. Trusova I. A. Kamaeva |
| author_facet | I. M. Gaiduk D. S. Korostovtsev N. L. Shaporova D. V. Breykin O. V. Trusova I. A. Kamaeva |
| author_sort | I. M. Gaiduk |
| collection | DOAJ |
| description | Aims of study: evaluation of immunological parameters in course of sublingual allergen-specific immunotherapy with tree pollen mixture in children with hay fever.Materials and methods: the study included one-hundred patients 5 to 18 years of age with hay fever (pollen rhinitis, rhinoconjunctivitis and/or asthma). Allergen-specific immunotherapy was administered pre-seasonally for three consecutive years. Cytokinechanges were studied in blood serum and in lavages from nasal cavity. Samples assessed before treatment and after 2nd and 3rd courses SLIT completion.Results: increased serum concentrations of IL-10, IFNγ, and decreased IL-4 contents were revealed in the course of treatment. No significant changes in cytokineconcentrations were detectable in nasal lavages.Conclusions: the changes revealed correspond to a shift of T cell response profile towards Th1 pathway, thus confirming pathogenetic effects of sublingual allergen-specific |
| format | Article |
| id | doaj-art-1c2c8340c2db4e2c91bbf07d82edf36e |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-1c2c8340c2db4e2c91bbf07d82edf36e2025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01151515410.15789/1563-0625-2013-1-51-5421CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVERI. M. Gaiduk0D. S. Korostovtsev1N. L. Shaporova2D. V. Breykin3O. V. Trusova4I. A. Kamaeva5Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова, Санкт-ПетербургСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-ПетербургСанкт-Петербургский государственный медицинский университет имени академика И.П. Павлова, Санкт-ПетербургСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-ПетербургСанкт-Петербургский государственный педиатрический медицинский университет, Санкт-ПетербургСанкт-Петербургский государственный медицинский университет имени академика И.П. Павлова, Санкт-ПетербургAims of study: evaluation of immunological parameters in course of sublingual allergen-specific immunotherapy with tree pollen mixture in children with hay fever.Materials and methods: the study included one-hundred patients 5 to 18 years of age with hay fever (pollen rhinitis, rhinoconjunctivitis and/or asthma). Allergen-specific immunotherapy was administered pre-seasonally for three consecutive years. Cytokinechanges were studied in blood serum and in lavages from nasal cavity. Samples assessed before treatment and after 2nd and 3rd courses SLIT completion.Results: increased serum concentrations of IL-10, IFNγ, and decreased IL-4 contents were revealed in the course of treatment. No significant changes in cytokineconcentrations were detectable in nasal lavages.Conclusions: the changes revealed correspond to a shift of T cell response profile towards Th1 pathway, thus confirming pathogenetic effects of sublingual allergen-specifichttps://www.mimmun.ru/mimmun/article/view/21сублингвальная аллерген-специфическая иммунотерапияаллергический ринитбронхиальная астмацитокиныдети |
| spellingShingle | I. M. Gaiduk D. S. Korostovtsev N. L. Shaporova D. V. Breykin O. V. Trusova I. A. Kamaeva CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER Медицинская иммунология сублингвальная аллерген-специфическая иммунотерапия аллергический ринит бронхиальная астма цитокины дети |
| title | CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER |
| title_full | CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER |
| title_fullStr | CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER |
| title_full_unstemmed | CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER |
| title_short | CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER |
| title_sort | changes of immune indexes during sublingual allergen specific immunotherapy in children with hay fever |
| topic | сублингвальная аллерген-специфическая иммунотерапия аллергический ринит бронхиальная астма цитокины дети |
| url | https://www.mimmun.ru/mimmun/article/view/21 |
| work_keys_str_mv | AT imgaiduk changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT dskorostovtsev changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT nlshaporova changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT dvbreykin changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT ovtrusova changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT iakamaeva changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever |