Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature
Generalized lymphadenopathy is a nonspecific sign with heterogenous etiology including infective, inflammatory, and malignant causes. We present the case of a child who presented with generalized lymphadenopathy, involving the cervical, axillary, mediastinal, and inguinal groups, along with recurrin...
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1795162 |
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| author | Mahin Mundra Vaishnavi Sreenivasan Nisha Swami Kawaldeep Kaur Bhavika Rishi Aroonima Misra Sumit Mehndiratta Amitabh Singh |
| author_facet | Mahin Mundra Vaishnavi Sreenivasan Nisha Swami Kawaldeep Kaur Bhavika Rishi Aroonima Misra Sumit Mehndiratta Amitabh Singh |
| author_sort | Mahin Mundra |
| collection | DOAJ |
| description | Generalized lymphadenopathy is a nonspecific sign with heterogenous etiology including infective, inflammatory, and malignant causes. We present the case of a child who presented with generalized lymphadenopathy, involving the cervical, axillary, mediastinal, and inguinal groups, along with recurring fever, tonsillar enlargement, and parotid swelling for 2 years. She had coexisting undernutrition and hepatosplenomegaly on examination. After ruling out common infective causes like tuberculosis, autoimmune and neoplastic conditions were considered. The diagnosis was made by histopathology of the axillary node biopsy, which revealed characteristic features of Rosai–Dorfman disease (RDD). She was started on oral steroids but was lost to follow-up after 6 months. We report this case to emphasize that RDD, a subtype of non-Langerhans histiocytosis, should be considered as a differential in young patients with persistent generalized lymphadenopathy. |
| format | Article |
| id | doaj-art-1c285af6ceba45a8bb4fdcfed5d1c6f3 |
| institution | Kabale University |
| issn | 0971-5851 0975-2129 |
| language | English |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-1c285af6ceba45a8bb4fdcfed5d1c6f32025-08-20T03:25:29ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-212910.1055/s-0044-1795162Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of LiteratureMahin Mundra0https://orcid.org/0009-0002-6741-2109Vaishnavi Sreenivasan1https://orcid.org/0009-0007-2118-3730Nisha Swami2Kawaldeep Kaur3Bhavika Rishi4https://orcid.org/0000-0002-5367-6050Aroonima Misra5https://orcid.org/0000-0003-2884-3600Sumit Mehndiratta6https://orcid.org/0000-0002-0024-8773Amitabh Singh7https://orcid.org/0000-0002-4440-5339Department of Pediatrics, VMMC & Safdarjung Hospital, New Delhi, IndiaDepartment of Pediatrics, VMMC & Safdarjung Hospital, New Delhi, IndiaDepartment of Pediatrics, VMMC & Safdarjung Hospital, New Delhi, IndiaDepartment of Pediatrics, VMMC & Safdarjung Hospital, New Delhi, IndiaNational Institute of Pathology, Indian Council of Medical Research (ICMR), New Delhi, IndiaNational Institute of Pathology, Indian Council of Medical Research (ICMR), New Delhi, IndiaDepartment of Pediatrics, VMMC & Safdarjung Hospital, New Delhi, IndiaDepartment of Pediatrics, VMMC & Safdarjung Hospital, New Delhi, IndiaGeneralized lymphadenopathy is a nonspecific sign with heterogenous etiology including infective, inflammatory, and malignant causes. We present the case of a child who presented with generalized lymphadenopathy, involving the cervical, axillary, mediastinal, and inguinal groups, along with recurring fever, tonsillar enlargement, and parotid swelling for 2 years. She had coexisting undernutrition and hepatosplenomegaly on examination. After ruling out common infective causes like tuberculosis, autoimmune and neoplastic conditions were considered. The diagnosis was made by histopathology of the axillary node biopsy, which revealed characteristic features of Rosai–Dorfman disease (RDD). She was started on oral steroids but was lost to follow-up after 6 months. We report this case to emphasize that RDD, a subtype of non-Langerhans histiocytosis, should be considered as a differential in young patients with persistent generalized lymphadenopathy.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1795162histiocytosisemperipolesislymphadenopathysteroids |
| spellingShingle | Mahin Mundra Vaishnavi Sreenivasan Nisha Swami Kawaldeep Kaur Bhavika Rishi Aroonima Misra Sumit Mehndiratta Amitabh Singh Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature Indian Journal of Medical and Paediatric Oncology histiocytosis emperipolesis lymphadenopathy steroids |
| title | Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature |
| title_full | Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature |
| title_fullStr | Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature |
| title_full_unstemmed | Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature |
| title_short | Persistent Generalized Lymphadenopathy: A Diagnostic Conundrum—Case Report and Review of Literature |
| title_sort | persistent generalized lymphadenopathy a diagnostic conundrum case report and review of literature |
| topic | histiocytosis emperipolesis lymphadenopathy steroids |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1795162 |
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