Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO
A computer simulation approach was developed to screen functional monomers for the rational design of molecularly imprinted polymers (MIPs). The proposed approach is based on a comparison of the binding energy of complexes, which are formed by the interaction between a template molecule and various...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-12-01
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| Series: | Adsorption Science & Technology |
| Online Access: | https://doi.org/10.1260/0263-6174.32.10.833 |
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| author | Sen Hou Yanfei Wang Na Liu Jing Liu |
| author_facet | Sen Hou Yanfei Wang Na Liu Jing Liu |
| author_sort | Sen Hou |
| collection | DOAJ |
| description | A computer simulation approach was developed to screen functional monomers for the rational design of molecularly imprinted polymers (MIPs). The proposed approach is based on a comparison of the binding energy of complexes, which are formed by the interaction between a template molecule and various functional monomers. According to the results of theoretical calculations, MIPs using thymopentin (TP5) as a template were prepared by a solution polymerization method, in which 2-methylacrylamide, N,N'-methylenebisacrylamide and poly(methylacrylic acid)/SiO 2 were used as the functional monomer, cross-linker and support, respectively. Solid-phase extraction experiments were performed, and static and dynamic binding properties of the synthesized MIP (i.e. TP5-MIP) for TP5 were studied. Results show that TP5-MIP exhibits excellent binding affinity and specific selectivity for the template molecule (i.e. TP5). |
| format | Article |
| id | doaj-art-1c1f588f1bdc4695b789ef7dfecaa31e |
| institution | Kabale University |
| issn | 0263-6174 2048-4038 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Adsorption Science & Technology |
| spelling | doaj-art-1c1f588f1bdc4695b789ef7dfecaa31e2025-02-03T10:08:09ZengSAGE PublishingAdsorption Science & Technology0263-61742048-40382014-12-013210.1260/0263-6174.32.10.833Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiOSen Hou0Yanfei Wang1Na Liu2Jing Liu3 Training Regiment of China Xi'an Satellite Control Center, Xi'an 714000, China School of Chemistry and Chemical Engineering, University of South of China, Hengyang 421001, China School of Chemistry and Chemical Engineering, University of South of China, Hengyang 421001, China School of Chemistry and Chemical Engineering, University of South of China, Hengyang 421001, ChinaA computer simulation approach was developed to screen functional monomers for the rational design of molecularly imprinted polymers (MIPs). The proposed approach is based on a comparison of the binding energy of complexes, which are formed by the interaction between a template molecule and various functional monomers. According to the results of theoretical calculations, MIPs using thymopentin (TP5) as a template were prepared by a solution polymerization method, in which 2-methylacrylamide, N,N'-methylenebisacrylamide and poly(methylacrylic acid)/SiO 2 were used as the functional monomer, cross-linker and support, respectively. Solid-phase extraction experiments were performed, and static and dynamic binding properties of the synthesized MIP (i.e. TP5-MIP) for TP5 were studied. Results show that TP5-MIP exhibits excellent binding affinity and specific selectivity for the template molecule (i.e. TP5).https://doi.org/10.1260/0263-6174.32.10.833 |
| spellingShingle | Sen Hou Yanfei Wang Na Liu Jing Liu Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO Adsorption Science & Technology |
| title | Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO |
| title_full | Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO |
| title_fullStr | Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO |
| title_full_unstemmed | Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO |
| title_short | Preparation and Recognition Characteristics of Thymopentin Molecularly Imprinted Polymers on SiO |
| title_sort | preparation and recognition characteristics of thymopentin molecularly imprinted polymers on sio |
| url | https://doi.org/10.1260/0263-6174.32.10.833 |
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