Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/403460 |
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| _version_ | 1832567151698903040 |
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| author | Yaw Kuang Chuah Rusliza Basir Herni Talib Tung Hing Tie Norshariza Nordin |
| author_facet | Yaw Kuang Chuah Rusliza Basir Herni Talib Tung Hing Tie Norshariza Nordin |
| author_sort | Yaw Kuang Chuah |
| collection | DOAJ |
| description | The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized. In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions. |
| format | Article |
| id | doaj-art-1c1ee8c8a2c2474eab86e0c6e7a098ae |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-1c1ee8c8a2c2474eab86e0c6e7a098ae2025-02-03T01:02:07ZengWileyInternational Journal of Inflammation2090-80402042-00992013-01-01201310.1155/2013/403460403460Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory DiseasesYaw Kuang Chuah0Rusliza Basir1Herni Talib2Tung Hing Tie3Norshariza Nordin4Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Pathology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, MalaysiaThe receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized. In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions.http://dx.doi.org/10.1155/2013/403460 |
| spellingShingle | Yaw Kuang Chuah Rusliza Basir Herni Talib Tung Hing Tie Norshariza Nordin Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases International Journal of Inflammation |
| title | Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases |
| title_full | Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases |
| title_fullStr | Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases |
| title_full_unstemmed | Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases |
| title_short | Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases |
| title_sort | receptor for advanced glycation end products and its involvement in inflammatory diseases |
| url | http://dx.doi.org/10.1155/2013/403460 |
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